Is GLA p.Arg356Gln (c.1067G>A) pathogenic?

GLA p.Arg356Gln (c.1067G>A) is classified Conflicting classifications of pathogenicity in GLA (ClinVar, Conflicting submitters, 11 submitters; last evaluated 2026-09-08). AlphaMissense: likely benign (0.0822); Very rare (popmax 0.00592%, eas); Associated with Fabry disease.

What condition is associated with GLA p.Arg356Gln (c.1067G>A)?

GLA p.Arg356Gln (c.1067G>A) is associated with Fabry disease (ClinVar).

How common is GLA p.Arg356Gln (c.1067G>A) in the general population?

GLA p.Arg356Gln (c.1067G>A) is very rare (popmax 0.00592%, eas) (gnomAD).

How is Fabry disease inherited?

Typically X-linked dominant, X-linked recessive (Orphanet). A genetic counselor can assess individual risk for a family.

What do computational predictors say about GLA p.Arg356Gln (c.1067G>A)?

AlphaMissense predicts likely benign (score 0.0822) — an in-silico prediction, not a clinical call.

GLA p.Arg356Gln

c.1067G>A · rs869312163 · VCV222135

Conflicting classifications of pathogenicity Conflicting submitters

Classification

Conflicting classifications of pathogenicity

ClinVar

Review

Conflicting submitters ★☆☆☆

ClinVar · 11 submitters

AlphaMissense

likely benign

0.0822 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00592%, eas)

Missense predictors

0/2 damaging

AlphaMissense, SaProt · REVEL no call

Conditions

Fabry disease

Computational evidence

Protein change
AlphaMissense	0.0822	likely benign
REVEL	0.53	indeterminate
SaProt	LLR -7.28	tolerated
⇒ AlphaMissense and SaProt both call this tolerated; REVEL makes no call.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 3.5	GERP 1, phastCons 1
Regional constraint	o/e 0.66	unconstrained · MANE · 6,067 bp · p 6.6e-08 · regional, not allelic
Overall
CADD	11.0	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00592% East Asian · 2/33,756 alleles

Filtering AF 0.0014% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.000688%

Overall 0.00124% 15/1,209,095 alleles · very rare

Ancestry group	Frequency	1 in
East Asiangrpmax	0.00592%	16,878
South Asian	0.00528%	18,948
Remaining individualsnot grpmax-eligible	0.00421%	23,778
African / African-American	0.0035%	28,591
European (non-Finnish)	0.000671%	149,053

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: GLA
Protein: p.Arg356Gln
Coding: c.1067G>A
MANE Select: NM_000169
dbSNP: rs869312163
Type: single nucleotide variant
Location: chrX:101398032 (GRCh38)
Structure: AlphaFold pLDDT 94.45 · 31 PDB
Residue 356: a UniProt-annotated variant site (in fabryd; loss of enzyme activity); a UniProt-annotated variant site (in fabryd; has 15% of wild-type activity); a UniProt-annotated variant site (in fabryd)

Full GLA gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Fabry disease — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For Fabry disease (Orphanet):

Inheritance: X-linked dominant, X-linked recessive
Onset: Adolescent, Adult, Childhood
Prevalence: 1-9 / 1 000 000 (Worldwide)

Similar variants

GLA p.Arg356Gly Pathogenic/Likely pathogenic ★★ ⚠ same residue
GLA p.Arg356Trp Pathogenic ★★ ⚠ same residue
GLA p.Arg356= Likely benign ★★ same residue
GLA p.Arg356Pro Likely pathogenic ★ ⚠ same residue
GLA p.Arg356fs Likely pathogenic ★ same residue
GLA c.1000-10G>A Likely pathogenic ★★ same condition
GLA c.1000-1G>A Pathogenic ★★ same condition
GLA c.1000-1G>C Pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/gla-p-arg356gln (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown