Is MAP2K1 p.Pro293Ala (c.877C>G) pathogenic?

MAP2K1 p.Pro293Ala (c.877C>G) is classified Uncertain significance in MAP2K1 (ClinVar, Single submitter, 1 submitter; last evaluated 2021-10-29). AlphaMissense: likely benign (0.06); Absent from gnomAD v4.1; Associated with Cardiovascular phenotype.

What condition is associated with MAP2K1 p.Pro293Ala (c.877C>G)?

MAP2K1 p.Pro293Ala (c.877C>G) is associated with Cardiovascular phenotype (ClinVar).

How common is MAP2K1 p.Pro293Ala (c.877C>G) in the general population?

MAP2K1 p.Pro293Ala (c.877C>G) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about MAP2K1 p.Pro293Ala (c.877C>G)?

AlphaMissense predicts likely benign (score 0.06) — an in-silico prediction, not a clinical call.

MAP2K1 p.Pro293Ala

c.877C>G · rs918690546 · VCV1764633

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.06 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

Cardiovascular phenotype

Computational evidence

Protein change
AlphaMissense	0.06	likely benign
REVEL	0.242	benign-leaning
SaProt	LLR -7.30	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 7.7	GERP 2, phastCons 1
Regional constraint	o/e 0.61	unconstrained · MANE · 5,593 bp · p 6.7e-08 · regional, not allelic
Overall
CADD	23.4	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: MAP2K1
Protein: p.Pro293Ala
Coding: c.877C>G
MANE Select: NM_002755
dbSNP: rs918690546
Type: single nucleotide variant
Location: chr15:66485173 (GRCh38)
Gene constraint: LOEUF 0.515 · pLI 0.97 · ClinGen HI 0/3 (gnomAD)
Structure: AlphaFold pLDDT 84.05 · 99 PDB
Residue 293: the protein kinase domain; the 'raf1-binding' region

Full MAP2K1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Cardiovascular phenotype — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

MAP2K1 p.Pro293Ser Uncertain significance ★ ⚠ same residue
MAP2K1 p.Pro293= Likely benign ★ same residue
MAP2K1 p.Ala268Val Uncertain significance ★★ ⚠ same condition
MAP2K1 p.Ala32Val Uncertain significance ★★ ⚠ same condition
MAP2K1 p.Arg108Gln Uncertain significance ★★ ⚠ same condition
MAP2K1 p.Arg291Gly Uncertain significance ★★ ⚠ same condition
MAP2K1 p.Asp217Asn Uncertain significance ★★ ⚠ same condition
MAP2K1 p.Asp267Glu Uncertain significance ★★ ⚠ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/map2k1-p-pro293ala (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown