Is MEN1 p.Glu466Val (c.1397A>T) pathogenic?

MEN1 p.Glu466Val (c.1397A>T) is classified Uncertain significance in MEN1 (ClinVar, Multiple submitters, 4 submitters; last evaluated 2025-08-17). AlphaMissense: likely benign (0.1898); Very rare (popmax 0.00136%, nfe); Associated with multiple endocrine neoplasia type 1.

What condition is associated with MEN1 p.Glu466Val (c.1397A>T)?

MEN1 p.Glu466Val (c.1397A>T) is associated with multiple endocrine neoplasia type 1, hereditary neoplastic syndrome (ClinVar).

How common is MEN1 p.Glu466Val (c.1397A>T) in the general population?

MEN1 p.Glu466Val (c.1397A>T) is very rare (popmax 0.00136%, nfe) (gnomAD).

How is Multiple endocrine neoplasia type 1 inherited?

Typically Autosomal dominant, Not applicable (Orphanet). A genetic counselor can assess individual risk for a family.

What do computational predictors say about MEN1 p.Glu466Val (c.1397A>T)?

AlphaMissense predicts likely benign (score 0.1898) — an in-silico prediction, not a clinical call.

MEN1 p.Glu466Val

c.1397A>T · rs1352053477 · VCV457293

Uncertain significance Multiple submitters

Classification

Uncertain significance

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 4 submitters

AlphaMissense

likely benign

0.1898 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00136%, nfe)

Conditions

multiple endocrine neoplasia type 1

Computational evidence

Protein change
AlphaMissense	0.1898	likely benign
REVEL	0.484	indeterminate
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 7.7	GERP 1.5, phastCons 1
Regional constraint	o/e 0.67	unconstrained · MANE · 344 bp · p 0.0075 · regional, not allelic
Overall
CADD	22.4	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

⚠ Isoform check: AlphaMissense numbered on a different transcript (AM E471V vs ClinVar E466V) — verify the residue.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00136% European (non-Finnish) · 16/1,178,620 alleles

Filtering AF 0.000804% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00065%

Overall 0.00107% 17/1,596,148 alleles · very rare

Ancestry group	Frequency	1 in
Remaining individualsnot grpmax-eligible	0.00161%	62,178
European (non-Finnish)grpmax	0.00136%	73,664

Remaining individuals shows a higher raw frequency than the grpmax group above it. gnomAD excludes bottlenecked groups — Finnish, Ashkenazi Jewish, Amish and “Remaining individuals” — from grpmax, because founder effects make their frequencies unrepresentative for filtering. The table is sorted by frequency, so an excluded group can sit above the grpmax row.

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: MEN1
Protein: p.Glu466Val
Coding: c.1397A>T
MANE Select: NM_001370259
dbSNP: rs1352053477
Type: single nucleotide variant
Location: chr11:64804770 (GRCh38)
Gene constraint: LOEUF 0.206 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 85.13 · 69 PDB
Residue 466: the 'disordered' region

Full MEN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

multiple endocrine neoplasia type 1 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary neoplastic syndrome

For Multiple endocrine neoplasia type 1 (Orphanet):

Inheritance: Autosomal dominant, Not applicable
Onset: All ages
Prevalence: 1-9 / 100 000 (Europe)

Similar variants

MEN1 p.Glu466Asp Uncertain significance ★★ same residue
MEN1 p.Glu466Gln Uncertain significance ★★ same residue
MEN1 p.Glu466Gly Uncertain significance ★★ same residue
MEN1 p.Glu466= Benign/Likely benign ★★ same residue
MEN1 p.Glu466Lys Conflicting classifications of pathogenicity ★ same residue
MEN1 p.Glu466fs Likely pathogenic ★ same residue
MEN1 p.Glu466Ter Likely pathogenic ★ same residue
MEN1 c.1049+1G>A Pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/men1-p-glu466val (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown