Is MEN1 p.Pro489Ala (c.1465C>G) pathogenic?

MEN1 p.Pro489Ala (c.1465C>G) is classified Uncertain significance in MEN1 (ClinVar, Single submitter, 1 submitter; last evaluated 2021-11-01). AlphaMissense: likely benign (0.0774); Absent from gnomAD v4.1; Associated with hereditary neoplastic syndrome.

What condition is associated with MEN1 p.Pro489Ala (c.1465C>G)?

MEN1 p.Pro489Ala (c.1465C>G) is associated with hereditary neoplastic syndrome (ClinVar).

How common is MEN1 p.Pro489Ala (c.1465C>G) in the general population?

MEN1 p.Pro489Ala (c.1465C>G) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about MEN1 p.Pro489Ala (c.1465C>G)?

AlphaMissense predicts likely benign (score 0.0774) — an in-silico prediction, not a clinical call.

MEN1 p.Pro489Ala

c.1465C>G · rs587778440 · VCV1773237

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely benign

0.0774 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
AlphaMissense	0.0774	likely benign
REVEL	0.393	indeterminate
SaProt	—	withheld · numbering disagrees past residue 150 · why
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 11	GERP 1.5, phastCons 1
Regional constraint	o/e 0.67	unconstrained · MANE · 344 bp · p 0.0075 · regional, not allelic
Overall
CADD	22.4	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL is an independent agreement signal.

⚠ Isoform check: AlphaMissense numbered on a different transcript (AM P494A vs ClinVar P489A) — verify the residue.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: MEN1
Protein: p.Pro489Ala
Coding: c.1465C>G
MANE Select: NM_001370259
dbSNP: rs587778440
Type: single nucleotide variant
Location: chr11:64804702 (GRCh38)
Gene constraint: LOEUF 0.206 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 85.13 · 69 PDB

Full MEN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

MEN1 p.Pro489Leu Uncertain significance ★★ same residue
MEN1 p.Pro489Ser Conflicting classifications of pathogenicity ★ same residue
MEN1 p.Pro489= Likely benign ★ same residue
MEN1 p.Pro489Thr Uncertain significance ★ same residue
MEN1 c.1049+1G>A Pathogenic ★★ same condition
MEN1 c.1049+1G>C Pathogenic ★★ same condition
MEN1 c.1350+1G>A Pathogenic ★★ same condition
MEN1 c.1351-2A>C Pathogenic/Likely pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/men1-p-pro489ala (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown