Is MSH6 p.Arg577fs (c.1729del) pathogenic?

MSH6 p.Arg577fs (c.1729del) is classified Pathogenic/Likely pathogenic in MSH6 (ClinVar, Multiple submitters, 4 submitters; last evaluated 2025-08-18). Absent from gnomAD; Associated with Hereditary nonpolyposis colorectal neoplasms.

What condition is associated with MSH6 p.Arg577fs (c.1729del)?

MSH6 p.Arg577fs (c.1729del) is associated with Hereditary nonpolyposis colorectal neoplasms, Lynch syndrome 5, hereditary neoplastic syndrome (ClinVar).

How common is MSH6 p.Arg577fs (c.1729del) in the general population?

MSH6 p.Arg577fs (c.1729del) is absent from gnomAD (gnomAD).

MSH6 p.Arg577fs

c.1729del · rs2104363773 · VCV1455637

Pathogenic/Likely pathogenic Multiple submitters

Classification

Pathogenic/Likely pathogenic

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 4 submitters

Consequence

frameshift

predicted LoF

gnomAD v4.1

Not reported

no gnomAD frequency available for this variant

Conditions

Hereditary nonpolyposis colorectal neoplasms

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Consequence	frameshift	predicted loss-of-function in a haploinsufficient gene (ClinGen)
NMD	predicted	premature termination codon in exon 4 of 10
Splicing
SpliceAI	—	not assessed · substitutions only
Constraint at this position
Conservation	phyloP 0.13	GERP -1.3, phastCons 0.98

Predicted loss-of-function is descriptive, not an applied PVS1 code.

Population frequency

dbSNP / gnomAD

No gnomAD frequency available for this variant. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.

Variant & gene context

Gene: MSH6
Protein: p.Arg577fs
Coding: c.1729del
MANE Select: NM_000179
dbSNP: rs2104363773
Type: Deletion
Location: chr2:47799712 (GRCh38)
Gene constraint: LOEUF 0.841 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 77.93 · 8 PDB

Full MSH6 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Hereditary nonpolyposis colorectal neoplasms — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: Lynch syndrome 5 hereditary neoplastic syndrome

Similar variants

MSH6 p.Arg577Ser Uncertain significance ★★ ⚠ same residue
MSH6 p.Arg577= Benign/Likely benign ★★ same residue
MSH6 p.Arg577Cys Conflicting classifications of pathogenicity ★ ⚠ same residue
MSH6 p.Arg577Gly Conflicting classifications of pathogenicity ★ ⚠ same residue
MSH6 p.Arg577His Conflicting classifications of pathogenicity ★ ⚠ same residue
MSH6 p.Arg577Leu Uncertain significance ★ ⚠ same residue
MSH6 c.3173-1_3173del Pathogenic ★★★ same condition
MSH6 c.3379_3438+5del Pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/msh6-p-arg577fs (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown