Is PALB2 p.Phe776= (c.2328C>T) pathogenic?

PALB2 p.Phe776= (c.2328C>T) is classified Benign/Likely benign in PALB2 (ClinVar, Multiple submitters, 13 submitters; last evaluated 2026-01-16). Very rare (popmax 0.00878%, sas); Associated with breast-ovarian cancer, familial, susceptibility to, 5.

What condition is associated with PALB2 p.Phe776= (c.2328C>T)?

PALB2 p.Phe776= (c.2328C>T) is associated with breast-ovarian cancer, familial, susceptibility to, 5, hereditary neoplastic syndrome, hereditary breast carcinoma (ClinVar).

How common is PALB2 p.Phe776= (c.2328C>T) in the general population?

PALB2 p.Phe776= (c.2328C>T) is very rare (popmax 0.00878%, sas) (gnomAD).

PALB2 p.Phe776=

c.2328C>T · rs45508997 · VCV225863

Benign/Likely benign Multiple submitters

Classification

Benign/Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 13 submitters

gnomAD v4.1

Rare

very rare (popmax 0.00878%, sas)

Conditions

breast-ovarian cancer, familial, susceptibility to, 5

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -3.3	GERP -3.7
Overall
CADD	1.995	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00878% South Asian · 8/91,086 alleles

Filtering AF 0.00437% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00312%

Overall 0.00149% 24/1,614,044 alleles · very rare exomes 22/1,461,882 · genomes 2/152,162 · joint denominator

Ancestry group	Frequency	1 in
South Asiangrpmax	0.00878%	11,386
African / African-American	0.00801%	12,487
Remaining individualsnot grpmax-eligible	0.0032%	31,244
East Asian	0.00223%	44,896
European (non-Finnish)	0.000593%	168,575

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: PALB2
Protein: p.Phe776=
Coding: c.2328C>T
MANE Select: NM_024675
dbSNP: rs45508997
Type: single nucleotide variant
Location: chr16:23629826 (GRCh38)
Gene constraint: LOEUF 0.9 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 54.07 · 4 PDB
Residue 776: the 'disordered' region; the 'required for interaction with polh and polh dna synthesis stimulation' region; a UniProt-annotated variant site (risk factor for brovca5); a UniProt-annotated variant site (in fancn; risk factor for brovca5)

Full PALB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

breast-ovarian cancer, familial, susceptibility to, 5 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hereditary neoplastic syndrome hereditary breast carcinoma

Similar variants

PALB2 p.Phe776Leu Conflicting classifications of pathogenicity ★ ⚠ same residue
PALB2 p.Phe776fs Pathogenic ★★ same residue
PALB2 c.3350+4A>G Likely pathogenic ★★★ same condition
PALB2 p.Arg1117Lys Pathogenic ★★★ ⚠ same condition
PALB2 p.Gln228Ter Pathogenic ★★★ same condition
PALB2 p.Gln692Ter Likely pathogenic ★★★ same condition
PALB2 p.Glu3Ter Pathogenic ★★★ same condition
PALB2 p.Gly853= Likely pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/palb2-p-phe776 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown