Is PALB2 p.Pro661Arg (c.1982C>G) pathogenic?

PALB2 p.Pro661Arg (c.1982C>G) is classified Uncertain significance in PALB2 (ClinVar, Multiple submitters, 8 submitters; last evaluated 2025-06-01). AlphaMissense: likely benign (0.1263); Absent from gnomAD v4.1; Associated with familial pancreatic carcinoma.

What condition is associated with PALB2 p.Pro661Arg (c.1982C>G)?

PALB2 p.Pro661Arg (c.1982C>G) is associated with familial pancreatic carcinoma, Fanconi anemia complementation group N, pancreatic cancer, susceptibility to, 3 (ClinVar).

How common is PALB2 p.Pro661Arg (c.1982C>G) in the general population?

PALB2 p.Pro661Arg (c.1982C>G) is absent from gnomAD v4.1 (gnomAD).

How is Familial pancreatic carcinoma inherited?

Typically Autosomal dominant, Multigenic/multifactorial (Orphanet). A genetic counselor can assess individual risk for a family.

What do computational predictors say about PALB2 p.Pro661Arg (c.1982C>G)?

AlphaMissense predicts likely benign (score 0.1263) — an in-silico prediction, not a clinical call.

PALB2 p.Pro661Arg

c.1982C>G · rs71379822 · VCV232550

Uncertain significance Multiple submitters

Classification

Uncertain significance

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 8 submitters

AlphaMissense

likely benign

0.1263 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

0/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

familial pancreatic carcinoma

Computational evidence

Protein change
AlphaMissense	0.1263	likely benign
REVEL	0.101	moderately benign-leaning
SaProt	LLR -6.41	tolerated
⇒ AlphaMissense, REVEL and SaProt all call this tolerated.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 2.1	GERP 1.9, phastCons 0.88
Regional constraint	o/e 1.00	unconstrained · MANE · 38 kb · p 0.87 · regional, not allelic
Overall
CADD	19.39	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean tolerated — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: PALB2
Protein: p.Pro661Arg
Coding: c.1982C>G
MANE Select: NM_024675
dbSNP: rs71379822
Type: single nucleotide variant
Location: chr16:23630172 (GRCh38)
Gene constraint: LOEUF 0.9 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 54.07 · 4 PDB
Residue 661: a UniProt-annotated variant site (risk factor for brovca5); a UniProt-annotated variant site (in fancn; risk factor for brovca5)

Full PALB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

familial pancreatic carcinoma — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: Fanconi anemia complementation group N pancreatic cancer, susceptibility to, 3 hereditary neoplastic syndrome hereditary breast carcinoma

For Familial pancreatic carcinoma (Orphanet):

Inheritance: Autosomal dominant, Multigenic/multifactorial
Onset: Adult
Prevalence: 1-9 / 1 000 000 (Europe)

Similar variants

PALB2 p.Pro661= Benign/Likely benign ★★ same residue
PALB2 p.Pro661Ser Uncertain significance ★ ⚠ same residue
PALB2 p.Pro661Leu Likely benign ★ same residue
PALB2 p.Pro661fs Pathogenic/Likely pathogenic ★★ same residue
PALB2 c.3350+4A>G Likely pathogenic ★★★ same condition
PALB2 p.Arg1117Lys Pathogenic ★★★ ⚠ same condition
PALB2 p.Gln228Ter Pathogenic ★★★ same condition
PALB2 p.Gln692Ter Likely pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/palb2-p-pro661arg (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown