Is PRSS1 p.Ala148Pro (c.442G>C) pathogenic?

PRSS1 p.Ala148Pro (c.442G>C) is classified Uncertain significance in PRSS1 (ClinVar, Single submitter, 1 submitter; last evaluated 2021-12-05). AlphaMissense: likely pathogenic (0.7493); Very rare (popmax 0.00158%, afr); Associated with hereditary chronic pancreatitis.

What condition is associated with PRSS1 p.Ala148Pro (c.442G>C)?

PRSS1 p.Ala148Pro (c.442G>C) is associated with hereditary chronic pancreatitis (ClinVar).

How common is PRSS1 p.Ala148Pro (c.442G>C) in the general population?

PRSS1 p.Ala148Pro (c.442G>C) is very rare (popmax 0.00158%, afr) (gnomAD).

What do computational predictors say about PRSS1 p.Ala148Pro (c.442G>C)?

AlphaMissense predicts likely pathogenic (score 0.7493) — an in-silico prediction, not a clinical call.

PRSS1 p.Ala148Pro

Q: How is Autosomal dominant hereditary chronic pancreatitis inherited?

Typically Autosomal dominant (Orphanet). A genetic counselor can assess individual risk for a family.

c.442G>C · rs775290386 · VCV1692720

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely pathogenic

0.7493 · ACMG-weighted

gnomAD v4.1

Rare

very rare (popmax 0.00158%, afr)

Missense predictors

2/2 damaging

AlphaMissense, SaProt · REVEL no call

Conditions

hereditary chronic pancreatitis

Computational evidence

Protein change
AlphaMissense	0.7493	likely pathogenic
REVEL	0.354	indeterminate
SaProt	LLR -10.01	damaging
⇒ AlphaMissense and SaProt both call this damaging; REVEL makes no call.
Splicing
SpliceAI	—	not looked up on this page · why
Constraint at this position
Conservation	phyloP -6.2	GERP -3.7
Regional constraint	o/e 1.20	unconstrained · MANE · 3,532 bp · p 0.00039 · regional, not allelic
Overall
CADD	11.59	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean damaging — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00158% African / African-American · 1/63,470 alleles

Overall 0.00159% 2/125,420 alleles · very rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.00158%	63,470
European (non-Finnish)	8.8e-05%	1,136,774

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: PRSS1
Protein: p.Ala148Pro
Coding: c.442G>C
dbSNP: rs775290386
Type: single nucleotide variant
Location: chr7:142752015 (GRCh38)

Full PRSS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary chronic pancreatitis — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For Autosomal dominant hereditary chronic pancreatitis (Orphanet):

Inheritance: Autosomal dominant
Onset: Adolescent, Childhood
Prevalence: 1-9 / 1 000 000 (France)

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/prss1-p-ala148pro (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown