RAD51C c.(?_21
Likely pathogenic
Single submitter
Classification
Likely pathogenic
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
Conditions
1
RAD51C-related cancer predisposition
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type. |
Variant & gene context
- Gene
- RAD51C
- Coding
- c.(?_21
- MANE Select
- NM_058216
- Type
- Deletion
- Gene constraint
- LOEUF 1.139 · pLI <0.01 · ClinGen HI 3/3 (gnomAD)
- Structure
- AlphaFold pLDDT 84.23 · 17 PDB
Similar variants
- RAD51C c.1026+5_1026+7del Pathogenic/Likely pathogenic ★★ same condition
- RAD51C p.Asp167fs Pathogenic ★★ same condition
- RAD51C p.Phe32fs Pathogenic/Likely pathogenic ★★ same condition
- RAD51C p.Ser353fs Conflicting classifications of pathogenicity ★ ⚠ same condition
- RAD51C c.404+2T>C Pathogenic/Likely pathogenic ★★ same condition
- RAD51C p.Arg193Ter Pathogenic/Likely pathogenic ★★ same condition
- RAD51C p.Arg319Ter Pathogenic ★★ same condition
- RAD51C p.Gln133Ter Pathogenic ★★ same condition
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/rad51c-c-21 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown