Is RET p.Ser365= (c.1095G>A) pathogenic?

RET p.Ser365= (c.1095G>A) is classified Conflicting classifications of pathogenicity in RET (ClinVar, Conflicting submitters, 8 submitters; last evaluated 2026-02-01). Very rare (popmax 0.00669%, eas); Associated with hereditary neoplastic syndrome.

What condition is associated with RET p.Ser365= (c.1095G>A)?

RET p.Ser365= (c.1095G>A) is associated with hereditary neoplastic syndrome, multiple endocrine neoplasia type 2B, multiple endocrine neoplasia type 2A (ClinVar).

How common is RET p.Ser365= (c.1095G>A) in the general population?

RET p.Ser365= (c.1095G>A) is very rare (popmax 0.00669%, eas) (gnomAD).

RET p.Ser365=

c.1095G>A · rs201992974 · VCV136094

Conflicting classifications of pathogenicity Conflicting submitters

Classification

Conflicting classifications of pathogenicity

ClinVar

Review

Conflicting submitters ★☆☆☆

ClinVar · 8 submitters

gnomAD v4.1

Rare

very rare (popmax 0.00669%, eas)

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation/SpliceAI carries the signal.
Splicing
SpliceAI	Δ0.55	acceptor gain · deltas
Constraint at this position
Conservation	phyloP -6.2	GERP -3.7
Overall
CADD	13.05	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00669% East Asian · 3/44,872 alleles

Filtering AF 0.00177% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.000891%

Overall 0.000868% 14/1,613,574 alleles · very rare exomes 9/1,461,330 · genomes 5/152,244 · joint denominator

Ancestry group	Frequency	1 in
East Asiangrpmax	0.00669%	14,957
African / African-American	0.004%	25,005
South Asian	0.0022%	45,539
Remaining individualsnot grpmax-eligible	0.0016%	62,506
European (non-Finnish)	0.000424%	236,003

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: RET
Protein: p.Ser365=
Coding: c.1095G>A
MANE Select: NM_020975
dbSNP: rs201992974
Type: single nucleotide variant
Location: chr10:43109062 (GRCh38)
Gene constraint: LOEUF 0.24 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 79.27 · 34 PDB
Residue 365: the 'cadherin-like region 3 (cld3)' region

Full RET gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: multiple endocrine neoplasia type 2B multiple endocrine neoplasia type 2A multiple endocrine neoplasia type 2

Similar variants

RET p.Ser365Trp Uncertain significance ★★ ⚠ same residue
RET p.Ser365Leu Conflicting classifications of pathogenicity ★ ⚠ same residue
RET c.1759+1G>A Pathogenic/Likely pathogenic ★★ same condition
RET c.1879+1G>A Pathogenic/Likely pathogenic ★★ same condition
RET p.Arg180Ter Pathogenic ★★ same condition
RET p.Arg77Cys Pathogenic/Likely pathogenic ★★ ⚠ same condition
RET p.Arg873Trp Likely pathogenic ★★ same condition
RET p.Arg897Ter Pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/ret-p-ser365 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown