RPL35 p.Arg89=
c.267T>C · rs370854864 · VCV2783518
Likely benign
Single submitter
Classification
Likely benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
very rare (popmax 0.00364%, nfe)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -0.91 | GERP -3.8 |
| Overall | ||
| CADD | 2.973 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
0.00364%
European (non-Finnish) · 43/1,180,028 alleles
Filtering AF
0.00275%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 0.00244%
Overall
0.00292%
47/1,612,334 alleles · very rare
| Ancestry group | Frequency | 1 in |
|---|---|---|
| European (non-Finnish)grpmax | 0.00364% | 27,443 |
| East Asian | 0.00223% | 44,896 |
| Admixed American | 0.00167% | 60,000 |
| Remaining individualsnot grpmax-eligible | 0.0016% | 62,344 |
| African / African-American | 0.00134% | 74,868 |
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- RPL35
- Protein
- p.Arg89=
- Coding
- c.267T>C
- MANE Select
- NM_007209
- dbSNP
- rs370854864
- Type
- single nucleotide variant
- Location
- chr9:124858023 (GRCh38)
- Gene constraint
- LOEUF 0.391 · pLI 0.99 (gnomAD)
- Structure
- AlphaFold pLDDT 94.73 · 188 PDB
- Residue 89
- an α-helix; the 'disordered' region
Similar variants
- RPL35 p.Ala120Thr Uncertain significance ★★ ⚠ same type
- RPL35 p.Arg109Gln Uncertain significance ★★ ⚠ same type
- RPL35 p.Arg109Leu Uncertain significance ★★ ⚠ same type
- RPL35 p.Arg112Trp Uncertain significance ★★ ⚠ same type
- RPL35 p.Arg117Gln Uncertain significance ★★ ⚠ same type
- RPL35 p.Arg94Trp Uncertain significance ★★ ⚠ same type
- RPL35 p.His98Gln Uncertain significance ★★ ⚠ same type
- RPL35 p.Ile47Met Uncertain significance ★★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/rpl35-p-arg89 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown