Is SOS2 p.Phe442= (c.1326C>T) pathogenic?

SOS2 p.Phe442= (c.1326C>T) is classified Likely benign in SOS2 (ClinVar, Multiple submitters, 4 submitters; last evaluated 2025-10-01). Ultra-rare (popmax 0.0165%, mid); Associated with Noonan syndrome 9.

What condition is associated with SOS2 p.Phe442= (c.1326C>T)?

SOS2 p.Phe442= (c.1326C>T) is associated with Noonan syndrome 9 (ClinVar).

How common is SOS2 p.Phe442= (c.1326C>T) in the general population?

SOS2 p.Phe442= (c.1326C>T) is ultra-rare (popmax 0.0165%, mid) (gnomAD).

SOS2 p.Phe442=

c.1326C>T · rs150365706 · VCV1626314

Likely benign Multiple submitters

Classification

Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 4 submitters

gnomAD v4.1

Rare

ultra-rare (popmax 0.0165%, mid)

Conditions

Noonan syndrome 9

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 1.8	GERP -1.8, phastCons 1
Overall
CADD	5.983	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.0165% Middle Eastern · 1/6,062 alleles

Filtering AF 0.00623% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00467%

Overall 0.00105% 17/1,614,062 alleles · ultra-rare exomes 14/1,461,846 · genomes 3/152,216 · joint denominator

Ancestry group	Frequency	1 in
Middle Easterngrpmax	0.0165%	6,062
African / African-American	0.012%	8,335
Remaining individualsnot grpmax-eligible	0.0032%	31,253
South Asian	0.0011%	91,078
European (non-Finnish)	0.000339%	295,002

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: SOS2
Protein: p.Phe442=
Coding: c.1326C>T
MANE Select: NM_006939
dbSNP: rs150365706
Type: single nucleotide variant
Location: chr14:50159957 (GRCh38)
Gene constraint: LOEUF 0.415 · pLI 1.00 · ClinGen HI 0/3 (gnomAD)
Structure: AlphaFold pLDDT 74.67 · 11 PDB
Residue 442: the ph domain

Full SOS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Noonan syndrome 9 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

SOS2 p.Phe442Cys Uncertain significance ★ ⚠ same residue
SOS2 p.Phe442Leu Uncertain significance ★ ⚠ same residue
SOS2 p.Met267Lys Likely pathogenic ★★★ ⚠ same condition
SOS2 p.Ala1195Val Uncertain significance ★★★ ⚠ same condition
SOS2 p.Arg225Gln Uncertain significance ★★★ ⚠ same condition
SOS2 p.Arg986Lys Uncertain significance ★★★ ⚠ same condition
SOS2 p.Thr1079Ala Uncertain significance ★★★ ⚠ same condition
SOS2 p.Asn867Ser Likely benign ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/sos2-p-phe442 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown