Is STRADA p.Val146Ala (c.437T>C) pathogenic?

STRADA p.Val146Ala (c.437T>C) is classified Uncertain significance in STRADA (ClinVar, Single submitter, 1 submitter; last evaluated 2023-12-17). AlphaMissense: likely pathogenic (0.6794); Absent from gnomAD v4.1; Associated with Inborn genetic diseases.

What condition is associated with STRADA p.Val146Ala (c.437T>C)?

STRADA p.Val146Ala (c.437T>C) is associated with Inborn genetic diseases (ClinVar).

How common is STRADA p.Val146Ala (c.437T>C) in the general population?

STRADA p.Val146Ala (c.437T>C) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about STRADA p.Val146Ala (c.437T>C)?

AlphaMissense predicts likely pathogenic (score 0.6794) — an in-silico prediction, not a clinical call.

STRADA p.Val146Ala

c.437T>C · rs2511103305 · VCV3171575

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely pathogenic

0.6794 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

3/3 damaging

AlphaMissense, REVEL, SaProt

Conditions

Inborn genetic diseases

Computational evidence

Protein change
AlphaMissense	0.6794	likely pathogenic
REVEL	0.705	pathogenic-leaning
SaProt	LLR -10.77	damaging
⇒ AlphaMissense, REVEL and SaProt all call this damaging.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 11	GERP 0.73, phastCons 1
Regional constraint	o/e 0.81	unconstrained · MANE · 25 kb · p 5.3e-06 · regional, not allelic
Overall
CADD	26.1	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean damaging — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: STRADA
Protein: p.Val146Ala
Coding: c.437T>C
MANE Select: NM_001003787
dbSNP: rs2511103305
Type: single nucleotide variant
Location: chr17:63710748 (GRCh38)
Gene constraint: LOEUF 0.649 · pLI <0.01 (gnomAD)
Structure: AlphaFold pLDDT 80.46 · 4 PDB
Residue 146: the protein kinase domain; a β-strand

Full STRADA gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Inborn genetic diseases — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Similar variants

STRADA p.Arg100Gln Uncertain significance ★★ ⚠ same condition
STRADA p.Arg13Leu Uncertain significance ★★ ⚠ same condition
STRADA p.Asp232Gly Uncertain significance ★★ ⚠ same condition
STRADA p.Asp428Asn Uncertain significance ★★ ⚠ same condition
STRADA p.Glu422Lys Uncertain significance ★★ ⚠ same condition
STRADA p.Glu70Lys Uncertain significance ★★ ⚠ same condition
STRADA p.Gly207Arg Uncertain significance ★★ ⚠ same condition
STRADA p.His223Asp Uncertain significance ★★ ⚠ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/strada-p-val146ala (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown