Is TEAD1 p.Ala205= (c.615C>G) pathogenic?

TEAD1 p.Ala205= (c.615C>G) is classified Likely benign in TEAD1 (ClinVar, Single submitter, 1 submitter; last evaluated 2022-07-06). Ultra-rare (popmax 0.012%, afr).

How common is TEAD1 p.Ala205= (c.615C>G) in the general population?

TEAD1 p.Ala205= (c.615C>G) is ultra-rare (popmax 0.012%, afr) (gnomAD).

TEAD1 p.Ala205=

c.615C>G · rs774352850 · VCV1558256

Likely benign Single submitter

Classification

Likely benign

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

gnomAD v4.1

Rare

ultra-rare (popmax 0.012%, afr)

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 0.69	GERP -1.6, phastCons 1
Overall
CADD	11.48	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.012% African / African-American · 9/74,916 alleles

Filtering AF 0.00624% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00468%

Overall 0.0018% 29/1,614,066 alleles · ultra-rare

Ancestry group	Frequency	1 in
African / African-Americangrpmax	0.012%	8,324
European (non-Finnish)	0.00169%	59,002

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: TEAD1
Protein: p.Ala205=
Coding: c.615C>G
MANE Select: NM_021961
dbSNP: rs774352850
Type: single nucleotide variant
Location: chr11:12883041 (GRCh38)
Gene constraint: LOEUF 0.276 · pLI 1.00 (gnomAD)
Structure: AlphaFold pLDDT 77.43 · 14 PDB
Residue 205: the 'transcriptional activation' region

Full TEAD1 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

TEAD1 p.Ala205Pro Uncertain significance ★★ ⚠ same residue
TEAD1 c.575-3C>T Uncertain significance ★★ same type
TEAD1 p.Ala123Val Uncertain significance ★★ same type
TEAD1 p.Ala188Thr Uncertain significance ★★ ⚠ same type
TEAD1 p.Ala200Val Uncertain significance ★★ ⚠ same type
TEAD1 p.Ala23Val Uncertain significance ★★ ⚠ same type
TEAD1 p.Arg147His Uncertain significance ★★ ⚠ same type
TEAD1 p.Arg229Gln Uncertain significance ★★ ⚠ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/tead1-p-ala205 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown