THRA p.Pro205=
c.615G>A · VCV3895591
Likely benign
Single submitter
Classification
Likely benign
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Rare
rare (popmax 0.147%, amr)
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP -4.6 | GERP -3.7 |
| Overall | ||
| CADD | 7.976 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Grpmax group
0.147%
Admixed American · 88/60,012 alleles
Filtering AF
0.122%
ClinGen BA1/BS1 input
FAF95, joint · FAF99 0.113%
Overall
0.0104%
168/1,614,092 alleles · rare
exomes 87/1,461,852 · genomes 81/152,240 · joint denominator
| Ancestry group | Frequency | 1 in |
|---|---|---|
| Admixed Americangrpmax | 0.147% | 682 |
| Remaining individualsnot grpmax-eligible | 0.0416% | 2,404 |
| African / African-American | 0.0173% | 5,769 |
| South Asian | 0.00329% | 30,361 |
| European (non-Finnish) | 0.00314% | 31,892 |
| Finnishnot grpmax-eligible | 0.00156% | 64,022 |
Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.
Variant & gene context
- Gene
- THRA
- Protein
- p.Pro205=
- Coding
- c.615G>A
- MANE Select
- NM_199334
- Type
- single nucleotide variant
- Location
- chr17:40086745 (GRCh38)
- Gene constraint
- LOEUF 0.439 · pLI 1.00 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 74.23 · 10 PDB
- Residue 205
- the nr lbd domain
Similar variants
- THRA p.Pro205Leu Uncertain significance ★ ⚠ same residue
- THRA p.Ala263Val Pathogenic/Likely pathogenic ★★ ⚠ same type
- THRA p.Glu403Lys Pathogenic/Likely pathogenic ★★ same type
- THRA p.Gly291Ser Pathogenic/Likely pathogenic ★★ same type
- THRA p.Met238Thr Uncertain significance ★★ ⚠ same type
- THRA c.223-5C>G Benign/Likely benign ★★ same type
- THRA p.Ala117= Benign ★★ same type
- THRA p.Asp246= Benign/Likely benign ★★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/thra-p-pro205 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown