Is THRB p.Glu445Asp (c.1335A>T) pathogenic?

THRB p.Glu445Asp (c.1335A>T) is classified Uncertain significance in THRB (ClinVar, Single submitter, 1 submitter; last evaluated 2018-05-08). AlphaMissense: likely pathogenic (0.7481); Absent from gnomAD v4.1.

How common is THRB p.Glu445Asp (c.1335A>T) in the general population?

THRB p.Glu445Asp (c.1335A>T) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about THRB p.Glu445Asp (c.1335A>T)?

AlphaMissense predicts likely pathogenic (score 0.7481) — an in-silico prediction, not a clinical call.

THRB p.Glu445Asp

c.1335A>T · rs1559387816 · VCV619916

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely pathogenic

0.7481 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

1/2 damaging

AlphaMissense, SaProt · REVEL no call

Computational evidence

Protein change
AlphaMissense	0.7481	likely pathogenic
REVEL	0.641	indeterminate
SaProt	LLR -3.90	tolerated
⇒ AlphaMissense calls this damaging; SaProt does not; REVEL makes no call.
Splicing
SpliceAI	Δ0.25	donor gain · deltas
Constraint at this position
Conservation	phyloP -0.8	GERP -4.1, phastCons 0.011
Regional constraint	o/e 0.15	constrained · MANE · 103 bp · p 5.9e-09 · regional, not allelic
Overall
CADD	22.7	PHRED · no single calibrated threshold — expert panels disagree

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: THRB
Protein: p.Glu445Asp
Coding: c.1335A>T
MANE Select: NM_001354712
dbSNP: rs1559387816
Type: single nucleotide variant
Location: chr3:24122935 (GRCh38)
Gene constraint: LOEUF 0.43 · pLI 1.00 (gnomAD)
Structure: AlphaFold pLDDT 80.24 · 34 PDB
Residue 445: the nr lbd domain; the 'interaction with nr2f6' region; an α-helix

Full THRB gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

PRSS1 p.Asn29Thr Pathogenic ★★ ⚠ same type
PRSS1 p.Lys23Arg Likely pathogenic ★★ ⚠ same type
THRB p.Ala268Gly Pathogenic/Likely pathogenic ★★ ⚠ same type
THRB p.Ala317Thr Pathogenic ★★ ⚠ same type
THRB p.Arg316His Pathogenic ★★ same type
THRB p.Arg320Cys Pathogenic ★★ same type
THRB p.Arg320His Pathogenic/Likely pathogenic ★★ same type
THRB p.Arg338Trp Pathogenic ★★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/thrb-p-glu445asp (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown