Is TP53 p.Ala355fs (c.1064_1091del) pathogenic?

TP53 p.Ala355fs (c.10641091del) is classified Uncertain significance in TP53 (ClinVar, Single submitter, 1 submitter; last evaluated 2026-02-01). Associated with Li-Fraumeni syndrome.

What condition is associated with TP53 p.Ala355fs (c.1064_1091del)?

TP53 p.Ala355fs (c.1064_1091del) is associated with Li-Fraumeni syndrome (ClinVar).

How is Li-Fraumeni syndrome inherited?

Typically Autosomal dominant (Orphanet). A genetic counselor can assess individual risk for a family.

TP53 p.Ala355fs

c.1064_1091del · VCV4713849

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

Consequence

frameshift

predicted LoF

gnomAD v4.1

Rare

Conditions

Li-Fraumeni syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Consequence	frameshift	predicted loss-of-function in a haploinsufficient gene (ClinGen)
NMD	escapes	premature termination codon within the last 50 nt of the penultimate exon (10 of 11, 9 nt from its 3' end) — the truncated protein is likely expressed. PVS1 input, not an applied code
Splicing
SpliceAI	—	not assessed · substitutions only
Constraint at this position
Conservation	phyloP 0.55	GERP -2.6, phastCons 0.39

Predicted loss-of-function is descriptive, not an applied PVS1 code.

Variant & gene context

Gene: TP53
Protein: p.Ala355fs
Coding: c.1064_1091del
MANE Select: NM_000546
Type: Deletion
Location: chr17:7670618 (GRCh38)
Gene constraint: LOEUF 0.449 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 75.83 · 321 PDB
Residue 355: the 'interaction with carm1' region; a turn; the 'interaction with hipk2' region; the 'oligomerization' region; the 'disordered' region; the 'interaction with hipk1' region

Full TP53 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

Li-Fraumeni syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For Li-Fraumeni syndrome (Orphanet):

Inheritance: Autosomal dominant
Onset: All ages
Prevalence: 1-9 / 100 000 (United Kingdom)

Similar variants

TP53 p.Ala355Asp Uncertain significance ★★ ⚠ same residue
TP53 p.Ala355Gly Conflicting classifications of pathogenicity ★ ⚠ same residue
TP53 p.Ala355Ser Conflicting classifications of pathogenicity ★ ⚠ same residue
TP53 p.Ala355Val Conflicting classifications of pathogenicity ★ ⚠ same residue
TP53 c.993+1del Likely pathogenic ★★★ same condition
TP53 p.Ala161_Tyr163delinsAsp Likely pathogenic ★★★ same condition
TP53 p.Arg213fs Pathogenic ★★★ same condition
TP53 p.Leu252_Ile254del Pathogenic ★★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/tp53-p-ala355fs (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown