Is TP53 p.Leu26fs (c.77_80delinsAAGAACGT) pathogenic?

TP53 p.Leu26fs (c.7780delinsAAGAACGT) is classified Pathogenic in TP53 (ClinVar, Single submitter, 2 submitters; last evaluated 2017-08-07). No gnomAD frequency available for this variant; Associated with hereditary neoplastic syndrome.

What condition is associated with TP53 p.Leu26fs (c.77_80delinsAAGAACGT)?

TP53 p.Leu26fs (c.77_80delinsAAGAACGT) is associated with hereditary neoplastic syndrome, Li-Fraumeni syndrome (ClinVar).

How common is TP53 p.Leu26fs (c.77_80delinsAAGAACGT) in the general population?

TP53 p.Leu26fs (c.77_80delinsAAGAACGT) is no gnomAD frequency available for this variant (gnomAD).

TP53 p.Leu26fs

c.77_80delinsAAGAACGT · rs397516438 · VCV43593

Pathogenic Single submitter

Classification

Pathogenic

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 2 submitters

Consequence

frameshift

predicted LoF

gnomAD v4.1

Not reported

no gnomAD frequency available for this variant

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Consequence	frameshift	predicted loss-of-function in a haploinsufficient gene (ClinGen)
NMD	predicted	premature termination codon in exon 3 of 11
Splicing
SpliceAI	—	not assessed · substitutions only
Constraint at this position
Conservation	phyloP 2.1	GERP 1.1, phastCons 0.91

Predicted loss-of-function is descriptive, not an applied PVS1 code.

Population frequency

dbSNP / gnomAD

No gnomAD frequency available for this variant. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.

Variant & gene context

Gene: TP53
Protein: p.Leu26fs
Coding: c.77_80delinsAAGAACGT
MANE Select: NM_000546
dbSNP: rs397516438
Type: Indel
Location: chr17:7676398 (GRCh38)
Gene constraint: LOEUF 0.449 · pLI 1.00 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 75.83 · 321 PDB
Residue 26: an α-helix; the 'interaction with ccar2' region; the 'interaction with hrmt1l2' region; the 'transcription activation (acidic)' region

Full TP53 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: Li-Fraumeni syndrome

Similar variants

TP53 p.Leu26= Benign/Likely benign ★★ same residue
TP53 p.Leu26Ile Uncertain significance ★ ⚠ same residue
TP53 p.Gly108_Leu111delinsIleGln Likely pathogenic ★★★ same condition
TP53 p.Pro72Cys Uncertain significance ★★★ same condition
TP53 p.Arg213Trp Pathogenic/Likely pathogenic ★★ same condition
TP53 p.Pro72Ser Uncertain significance ★★ same condition
TP53 c.96+15_96+31delinsC Likely benign ★★ same condition
TP53 c.376-70_394delinsG Pathogenic ★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/tp53-p-leu26fs (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown