Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 9/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | RAD52 | P43351 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10000193 | 0.85 | KDM1A (0.76) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL13889178 | 0.73 | KDM1A (1.00) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL27212831 | 0.72 | KMT2A (1.00) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL902770 | 0.71 | KDM1A (1.00) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL17154443 | 0.70 | KDM1A (0.63) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL1387165 | 0.70 | ERBB2 (1.00) | RAD52ERBB2RAF1MAP2K1KDR | |
| Hydrochloric Acid SCHEMBL15673452 | 0.69 | KDM1A (0.96) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL20856844 | 0.69 | KMT2A (0.68) | KDM1AKMT2ARAD52POLBGFER | |
| SCHEMBL27707570 | 0.69 | MAP2K1 (1.00) | ERBB2RAF1MAP2K1KDRTEK | |
| SCHEMBL10000194 | 0.69 | ERBB2 (0.94) | RAD52ERBB2KDRTEKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | KDM1A 2274/4885KMT2A 1536/4885RAD52 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.