Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31098947 | 0.88 | RAB9A (0.59) | KDREGFRRAB9ANPC1HTT | |
| SCHEMBL1921849 | 0.84 | ABCG2 (0.53) | ERBB2TTBK1TTBK2EGFRRAB9A | |
| SCHEMBL30012613 | 0.84 | EPHX2 (0.56) | TTBK1TTBK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23607654 | 0.84 | EPHX2 (0.56) | TTBK1TTBK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3759489 | 0.83 | F12 (0.52) | KDREGFRRAB9ANPC1HTT | |
| Hydrochloric Acid SCHEMBL30012600 | 0.83 | EPHX2 (0.55) | TTBK1TTBK2RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23607653 | 0.83 | EPHX2 (0.55) | TTBK1TTBK2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4497329 | 0.82 | ABCG2 (0.58) | TTBK1TTBK2EGFRRAB9ANPC1 | |
| SCHEMBL20356687 | 0.82 | NPC1 (0.56) | EGFRRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL20852287 | 0.82 | EGFR (0.60) | KDREGFRRAB9ANPC1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2011016952-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | KDR 2824/4885TEK 1710/4885ERBB2 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.