Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 3/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347216 | 1.00 | RECQL (0.64) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL347217 | 1.00 | RECQL (0.64) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL11844408 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL28990052 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL11844414 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL17412169 | 0.88 | RECQL (0.61) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL1163060 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL1163058 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL1163061 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL30267571 | 0.82 | RECQL (0.70) | RECQLPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782579-B1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARM INC (US) | 2019-01-02 | — | — | EP | disclosed |
| CN-104066431-B | Pyrazine kinase inhibitors | 波托拉医药品公司 | 2017-03-08 | — | — | CN | disclosed |
| US-9359308-B2 | Pyrazine kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| WO-2016003225-A2 | COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING SAME, AND ELECTRONIC DEVICE COMPRISING SAME | 덕산네오룩스 주식회사 | 2016-01-07 | — | — | WO | disclosed |
| US-8877760-B2 | Substituted pyrazine-2-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20140309209-A1 | Pyrazine Kinase Inhibitors | ALEXION PHARMACEUTICALS, INC. | 2014-10-16 | — | — | US | disclosed |
| EP-2782579-A1 | PYRAZINE KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2014-10-01 | — | — | EP | disclosed |
| CN-101397291-B | Method for preparing 2-cyanoacet-5-substituted thiophenes compound | SHANGHAI CHEMPERTNER CHEMICAL RES CO LTD | 2013-09-11 | — | — | CN | disclosed |
| US-8475686-B2 | Bridged pyridoquinazoline or phenanthroline compounds and organic semiconducting material comprising that compound | NOVALED AG (DE) | 2013-07-02 | — | — | US | disclosed |
| US-8475686-B2 | Bridged pyridoquinazoline or phenanthroline compounds and organic semiconducting material comprising that compound | NOVALED AG (DE) | 2013-07-02 | — | — | US | disclosed |
| WO-2010069877-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES FOR USE AS PLANT GROWTH REGULATORS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010063461-A1 | BRIDGED PYRIDOQUINAZOLINE OR PHENANTHROLINE COMPOUNDS AND ORGANIC SEMICONDUTING MATERIAL COMPRISING THAT COMPOUND | NOVALED AG (DE) | 2010-06-10 | — | — | WO | disclosed |
| EP-2194055-A1 | Bridged pyridoquinazoline or phenanthroline compounds and organic semiconducting material comprising that compound | Novaled AG (DE) | 2010-06-09 | — | — | EP | disclosed |
| CN-101397291-A | Method for preparing 2-cyanoacet-5-substituted thiophenes compound | SHANGHAI CHEMPERTNER CHEMICAL (CN) | 2009-04-01 | — | — | CN | disclosed |
| WO-2009007098-A1 | ISOTHIAZOLE AND PYRAZOLE DERIVATIVES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| EP-0129407-A2 | Improvements in and relating to (3-aryl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309209-A1 | Pyrazine Kinase Inhibitors | SYK, ZAP70, LCK | RECQL 2781/4885PRSS1 876/4885PRSS2 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.