Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 3/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | C1S | P09871 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL347216 | 1.00 | RECQL (0.64) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL10001025 | 1.00 | RECQL (0.64) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL11844408 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL28990052 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL11844414 | 0.88 | RECQL (0.79) | RECQLPOLBPDE4APDE4BPDE4C | |
| SCHEMBL17412169 | 0.88 | RECQL (0.61) | RECQLPRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL1163060 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL1163058 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL1163061 | 0.83 | RECQL (0.56) | RECQLKMT2AF2F10TSHR | |
| SCHEMBL30267571 | 0.82 | RECQL (0.70) | RECQLPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3970622-A | Heat stabilizers for polyvinyl chloride (β-amino-β-arylacrylonitriles) | AMERICAN CYANAMID COMPANY (US) | 1976-07-20 | — | — | US | claimed |
| CN-113845443-A | Preparation method and intermediate of 2-cyano-3-amino acrylate compound | 江苏省农药研究所股份有限公司 | 2021-12-28 | — | — | CN | disclosed |
| CN-113444037-A | Green synthesis method of nicotinic acid ester compound based on nonmetal condition | 安阳师范学院 | 2021-09-28 | — | — | CN | disclosed |
| CN-113402424-A | Synthetic method of cyanoacrylate compound | 上海泰初化工技术有限公司 | 2021-09-17 | — | — | CN | disclosed |
| CN-111116416-A | Preparation method of β -amino acrylonitrile compound | 中国农业大学 | 2020-05-08 | — | — | CN | disclosed |
| EP-2782579-B1 | PYRAZINE KINASE INHIBITORS | PORTOLA PHARM INC (US) | 2019-01-02 | — | — | EP | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |
| US-9359308-B2 | Pyrazine kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0799206-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019455-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |
| EP-0129407-A2 | Improvements in and relating to (3-aryl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |
| US-3970644-A | Heat stabilizers for polyvinyl chloride (β-amino-β-arylacrylamides) | AMERICAN CYANAMID COMPANY (US) | 1976-07-20 | — | — | US | disclosed |
| US-3970622-A | Heat stabilizers for polyvinyl chloride (β-amino-β-arylacrylonitriles) | AMERICAN CYANAMID COMPANY (US) | 1976-07-20 | — | — | US | disclosed |