Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 15/20 | 0.44 |
| ▸ | UBA3 | Q8TBC4 | 14/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.44 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | UBA1 | P22314 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10233944 | 0.84 | NAE1 (0.48) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL191755 | 0.83 | NAE1 (0.63) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865937 | 0.81 | NAE1 (0.44) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865938 | 0.81 | NAE1 (0.44) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865981 | 0.77 | NAE1 (0.47) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL12984837 | 0.76 | UBA6 (0.43) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL17865982 | 0.75 | NAE1 (0.41) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL12984834 | 0.75 | NAE1 (0.39) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL10233939 | 0.74 | NAE1 (0.56) | NAE1UBA3CA2GRK5CSNK1A1 | |
| SCHEMBL13193538 | 0.74 | NAE1 (0.56) | NAE1UBA3CA2GRK5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989206-B1 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARM INC (US) | 2012-07-04 | — | — | EP | disclosed |