Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 7/20 | 0.35 |
| ▸ | KDM1A | O60341 | 7/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10012996 | 0.92 | ENPP1 (0.37) | ENPP1EGFR | |
| SCHEMBL2836576 | 0.78 | ENPP1 (0.39) | ENPP1EGFRKDM1APDE3AKDR | |
| SCHEMBL2833438 | 0.78 | P2RX7 (0.43) | ENPP1EGFRKDM1APDE3AKDR | |
| SCHEMBL2837582 | 0.76 | EGFR (0.42) | ENPP1EGFRKDM1AKDR | |
| SCHEMBL13091013 | 0.76 | ENPP1 (0.38) | ENPP1EGFRKDM1APDE3A | |
| SCHEMBL2830929 | 0.73 | ABCG2 (0.44) | ENPP1EGFR | |
| SCHEMBL2836613 | 0.69 | EGFR (0.39) | ENPP1EGFR | |
| SCHEMBL2836110 | 0.69 | P2RX7 (0.44) | ENPP1EGFR | |
| SCHEMBL2833476 | 0.68 | EGFR (0.39) | EGFRKDR | |
| SCHEMBL2840274 | 0.67 | ENPP1 (0.49) | ENPP1EGFRKDM1APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172380-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | NATCO PHARMA LIMITED (IN) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172380-A1 | NOVEL 4-(TETRAZOL-5-YL)-QUINAZOLINE DERIVATIVES AS ANTI CANCER AGENT | MKI67, CDKL5, CCNI | ENPP1 2315/4885EGFR 1213/4885KDM1A 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.