P2RX7 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL106039	1.00	20/20
SCHEMBL106213	1.00	20/20
SCHEMBL106337	1.00	20/20
SCHEMBL106357	1.00	20/20
SCHEMBL106686	1.00	20/20
SCHEMBL106746	1.00	20/20
SCHEMBL106844	1.00	20/20
SCHEMBL106860	1.00	20/20
SCHEMBL106881	1.00	20/20
SCHEMBL106922	1.00	20/20
SCHEMBL106936	1.00	20/20
SCHEMBL106954	1.00	20/20
SCHEMBL107128	1.00	20/20
SCHEMBL107154	1.00	20/20
SCHEMBL107221	1.00	20/20
SCHEMBL107307	1.00	20/20
SCHEMBL107332	1.00	20/20
SCHEMBL107342	1.00	20/20
SCHEMBL107348	1.00	20/20
SCHEMBL107391	1.00	20/20

Clinical trials — most relevant to P2RX7 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine	PHASE4	COMPLETED
H2 Haplotype and CYP3As Polymorphisms and the Antiplatelet Response to Clopidogrel	PHASE4	COMPLETED
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks	PHASE3	WITHDRAWN
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.	PHASE2	NOT_YET_RECRUITING
First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Assending Doses of GSK1482160.	PHASE1	COMPLETED
A Multiple-Dose Escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of HS-10383	PHASE1	UNKNOWN
A Safety Study Of A Single Vaginal Administration Of P2G12 Antibody In Healthy Female Subjects	PHASE1	COMPLETED
A Study of ES002023 (Anti-CD39 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors	PHASE1	COMPLETED
Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults	EARLY_PHASE1	COMPLETED
Peripheral KV7 Activation for Pain Relief	EARLY_PHASE1	COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8	EARLY_PHASE1	COMPLETED
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients	nan	RECRUITING
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients	nan	COMPLETED
The Real-world Treatment Satisfaction by Gefapixiant in RCC	nan	RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
Suppressive Functions of Regulatory T Cells in Migraine	nan	NOT_YET_RECRUITING
P2X7 Receptor, Inflammation and Neurodegenerative Diseases	nan	COMPLETED
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Cytokines in Papillon-Lefèvre Syndrome	nan	COMPLETED
ATP and P2X3 Receptor in Chronic Cough	nan	UNKNOWN
Salts of Clopidogrel: Investigation to ENsure Clinical Equivalence	nan	COMPLETED
Local Injection of Botulinium Toxin-A in Children With Dysfunctional Voiding or Refractory Nocturnal Eneuresis	nan	RECRUITING
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients	nan	COMPLETED
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Remote Ischemic Preconditioning in Patients Undergoing Acute Minor Abdominal Surgery	nan	COMPLETED
The Role of Urinary ATP in the Diagnosis, Treatment, and Follow-up of Children With Overactive Bladder	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a P2RX7 binder may also engage these)

Protein	Name	Similarity
Q64663	—	1.000	Q64663 →
Q9Z1M0	—	1.000	Q9Z1M0 →
P2RX5	P2X purinoceptor 5	0.994	landscape →
Q9BDK6	—	0.988	Q9BDK6 →
Q91VE2	—	0.988	Q91VE2 →
P2RX3	P2X purinoceptor 3	0.987	landscape →
P51578	—	0.987	P51578 →
Q99ME6	—	0.986	Q99ME6 →
P78363	—	0.986	P78363 →
Q9UN42	—	0.986	Q9UN42 →
P0DP43	—	0.986	P0DP43 →
O95477	—	0.985	O95477 →
A7MB71	—	0.985	A7MB71 →
O88870	—	0.985	O88870 →
Q95JI2	—	0.985	Q95JI2 →
Q95JR7	—	0.985	Q95JR7 →
P51914	—	0.984	P51914 →
Q6W3E5	—	0.984	Q6W3E5 →
P63057	—	0.984	P63057 →
P63056	—	0.984	P63056 →
Q5E9U1	—	0.984	Q5E9U1 →
Q7T047	—	0.984	Q7T047 →
O22757	—	0.984	O22757 →
Q3TT99	—	0.984	Q3TT99 →
P51579	—	0.983	P51579 →
Q9DC11	—	0.983	Q9DC11 →
P49654	—	0.983	P49654 →
D3YWQ0	—	0.983	D3YWQ0 →
P25305	—	0.983	P25305 →
B5E0H4	—	0.983	B5E0H4 →