Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 19/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10019215 | 0.81 | EPHX2 (1.00) | EPHX2GAAHTT | |
| SCHEMBL10019218 | 0.80 | EPHX2 (1.00) | EPHX2GAAHTT | |
| SCHEMBL10019212 | 0.79 | EPHX2 (1.00) | EPHX2GAAHTT | |
| SCHEMBL10019217 | 0.79 | EPHX2 (1.00) | EPHX2GAAHTT | |
| SCHEMBL30924049 | 0.78 | EPHX2 (0.64) | EPHX2GAAHTT | |
| SCHEMBL10019220 | 0.76 | EPHX2 (0.73) | EPHX2 | |
| SCHEMBL21765931 | 0.76 | SLC13A5 (0.82) | EPHX2GAAHTT | |
| SCHEMBL10019216 | 0.75 | EPHX2 (1.00) | EPHX2 | |
| SCHEMBL30924045 | 0.75 | ACKR3 (0.62) | EPHX2GAAHTT | |
| SCHEMBL13882047 | 0.75 | P2RX7 (0.61) | EPHX2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005732-B2 | Potent non-urea inhibitors of soluble epoxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005732-B2 | Potent non-urea inhibitors of soluble epoxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-26 | — | — | US | disclosed |
| US-9175285-B2 | Potent non-urea inhibitors of soluble epdxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-03 | — | — | US | disclosed |
| US-9175285-B2 | Potent non-urea inhibitors of soluble epdxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140349368-A1 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140349368-A1 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-11-27 | — | — | US | disclosed |
| US-8653273-B2 | Potent non-urea inhibitors of soluble epoxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653273-B2 | Potent non-urea inhibitors of soluble epoxide hydrolase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-02-18 | — | — | US | disclosed |
| US-20120029022-A1 | Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase | THE TRUSTEES OF COLUMBIA UNIVESITY IN THE CITY OF NEW YORK (US) | 2012-02-02 | — | — | US | disclosed |
| US-20120029022-A1 | Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase | THE TRUSTEES OF COLUMBIA UNIVESITY IN THE CITY OF NEW YORK (US) | 2012-02-02 | — | — | US | disclosed |
| WO-2010080183-A1 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349368-A1 | POTENT NON-UREA INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | EPHX1, EPHX2, ECE1 | EPHX2 2/4885GAA 2234/4885HTT 4409/4885 |
| US-20120029022-A1 | Potent Non-Urea Inhibitors Of Soluble Epoxide Hydrolase | EPHX1, EPHX2, ECE1 | EPHX2 2/4885GAA 2234/4885HTT 4409/4885 |
| US-10005732-B2 | Potent non-urea inhibitors of soluble epoxide hydrolase | EPHX1, EPHX2, ECE1 | EPHX2 2/4885GAA 2234/4885HTT 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.