SCHEMBL10019675

SCHEMBL10019675

CCCc1ccc(OC(=O)c2ccc3c(c2F)C(F)C(F)c2c-3ccc(OCC)c2F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
KMT2A Q03164 1/20 0.34
MAPT P10636 2/20 0.34
THRB P10828 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
CASP3 P42574 1/20 0.33
RAB9A P51151 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.32
TSHR P16473 1/20 0.32
CPS1 P31327 2/20 0.32
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
CTSL P07711 1/20 0.31
CTSS P25774 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15257969 0.91 ESR1 (0.39) ESR1ESR2KMT2AMAPTTHRB
SCHEMBL10019680 0.90 ESR1 (0.33) ESR1ESR2KMT2AMAPTTHRB
SCHEMBL10019687 0.88 ESR1 (0.37) ESR1ESR2KMT2AMAPTTHRB
SCHEMBL10019368 0.88 CTSL (0.37) GABRA1GABRB2CTSLCTSSCTSK
SCHEMBL15257973 0.87 MAPT (0.44) ESR1ESR2KMT2AMAPTTHRB
SCHEMBL10020051 0.86 CTSL (0.37) SMN1; SMN2LMNAGABRA1GABRB2CTSL
SCHEMBL19621901 0.86 CTSL (0.37) SMN1; SMN2LMNAGABRA1GABRB2CTSL
SCHEMBL10019659 0.86 KDM4E (0.41) MAPTSMN1; SMN2KDM4ELMNACPS1
SCHEMBL15257974 0.85 KDM4E (0.39) ESR1ESR2KMT2AMAPTTHRB
SCHEMBL10019637 0.85 PRSS1 (0.39) KMT2AMAPTSMN1; SMN2NPC1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2669263-B1 COMPOUND CONTAINING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORP (JP) 2017-11-22 EP disclosed
US-9193908-B2 Compound having dihydrophenanthrene, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-11-24 US disclosed
US-9193908-B2 Compound having dihydrophenanthrene, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2015-11-24 US disclosed
US-20130240784-A1 COMPOUND HAVING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-09-19 US disclosed
US-20130240784-A1 COMPOUND HAVING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC PETROCHEMICAL CORPORATION (JP) 2013-09-19 US disclosed
WO-2012086437-A1 COMPOUND CONTAINING DIHYDROPHENANTHRENE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY JNC株式会社 (JP) 2012-06-28 WO disclosed