Sugi Predict

Sugi Predict / Targets / CTSL

CTSL

Procathepsin L · P07711 · CTSL on Sugi Atlas →

267,304 patent compounds predicted against CTSL, 148,133 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL115059 SCHEMBL115059 0.52 12/20
SCHEMBL52449 SCHEMBL52449 0.52 10/20
Mg-132 Mg-132 (SCHEMBL160925) 0.72 9/20
SCHEMBL51465 SCHEMBL51465 0.49 9/20
SCHEMBL142589 SCHEMBL142589 0.46 9/20
Telaprevir Telaprevir (SCHEMBL183996) 1.00 8/20
Telaprevir Telaprevir (SCHEMBL184177) 1.00 8/20
SCHEMBL87370 SCHEMBL87370 0.51 8/20
SCHEMBL52043 SCHEMBL52043 0.48 7/20
SCHEMBL56757 SCHEMBL56757 0.48 7/20
SCHEMBL192070 SCHEMBL192070 0.47 7/20
SCHEMBL191969 SCHEMBL191969 0.45 7/20
SCHEMBL142588 SCHEMBL142588 0.44 7/20
SCHEMBL25562 SCHEMBL25562 0.36 7/20
SCHEMBL159283 SCHEMBL159283 0.60 6/20
Water Water (SCHEMBL44988) 0.56 6/20
SCHEMBL190803 SCHEMBL190803 0.54 6/20
SCHEMBL40779 SCHEMBL40779 0.54 6/20
SCHEMBL40780 SCHEMBL40780 0.54 6/20
SCHEMBL53069 SCHEMBL53069 0.53 6/20

Clinical trials — most relevant to CTSL by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Anti-CD14 Treatment With IC14 in Hospitalized ARDS Patients PHASE2RECRUITING
Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19 PHASE2UNKNOWN
DEFINE - Evaluating Therapies for COVID-19 PHASE1/PHASE2COMPLETED
Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia PHASE2COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast PHASE2COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study nanNOT_YET_RECRUITING
ICIS in Burn Patients Compared to Other Inflammatory Markers nanCOMPLETED
Utility of Presepsin in Children Sepsis nanUNKNOWN
Neutrophil Gelatinase-associated Lipocalin (NGAL) Evaluation in Emergency Department (ED) All-Comers nanCOMPLETED
Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients nanRECRUITING
Presepsin Biomarker for Ventilator-associated Pneumonia Diagnosis in COVID-19 Patients nanUNKNOWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Use of Presepsin in the Emergency Department nanUNKNOWN
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery nanCOMPLETED
Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients nanCOMPLETED
NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction nanUNKNOWN
Utility of Presepsin in Distinguishing Between Sepsis and SIRS nanCOMPLETED
Search for Biomarkers of Infection and Inflammation in Patients With Acute Stroke. nanUNKNOWN
Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood. nanNOT_YET_RECRUITING
The Role of Pentraxin 3 and Cathepsin B Levels in Preeclamptic Pregnancy nanCOMPLETED
Host Response Mediators in Coronavirus (COVID-19) Infection nanUNKNOWN
MMP-9/NGAL Modulation by Piper Crocatum in Early Diabetic Nephropathy nanCOMPLETED
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery nanRECRUITING
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy nanCOMPLETED
Utility of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Predicting Renal Impairment, Further Decompensation and Rehospitalization in Acutely Decompensated and Chronic Heart Failure Patients nanCOMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain nanCOMPLETED
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis nanCOMPLETED
Presepsin as a Predictor for Postoperative Complications Following Pancreatic Resection nanCOMPLETED
Plasma Neutrophil Gelatinase Associated Lipocalin Levels During Emergency Management of Rhabdomyolysis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CTSL binder may also engage these)

ProteinNameSimilarity
Q9GKL8 — 1.000 Q9GKL8 →
P06797 — 0.998 P06797 →
Q9GL24 — 0.997 Q9GL24 →
CTSV Cathepsin L2 0.997 landscape →
P25975 — 0.994 P25975 →
Q5E998 — 0.994 Q5E998 →
P25773 — 0.994 P25773 →
Q28944 — 0.993 Q28944 →
P55097 — 0.993 P55097 →
Q5E968 — 0.992 Q5E968 →
P25326 — 0.992 P25326 →
A0A1S4F2V5 — 0.992 A0A1S4F2V5 →
Q26636 — 0.992 Q26636 →
CTSS Cathepsin S 0.991 landscape →
P07154 — 0.991 P07154 →
O70370 — 0.990 O70370 →
O45734 — 0.989 O45734 →
P61276 — 0.989 P61276 →
P25784 — 0.989 P25784 →
Q3ZKN1 — 0.989 Q3ZKN1 →
Q95029 — 0.989 Q95029 →
O35186 — 0.989 O35186 →
Q9GLE3 — 0.988 Q9GLE3 →
P61277 — 0.988 P61277 →
CTSK Cathepsin K 0.987 landscape →
P43236 — 0.986 P43236 →
Q02765 — 0.986 Q02765 →
P12412 — 0.986 P12412 →
Q80UB0 — 0.986 Q80UB0 →
Q63088 — 0.985 Q63088 →