Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10053628 | 0.87 | ROCK2 (0.65) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL6293584 | 0.85 | ROCK2 (0.73) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022538 | 0.82 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022536 | 0.82 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022451 | 0.82 | ROCK2 (0.68) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022524 | 0.82 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022498 | 0.82 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10159996 | 0.81 | ROCK2 (0.73) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL10022517 | 0.81 | ROCK2 (0.77) | ROCK2ROCK1 | |
| SCHEMBL307814 | 0.81 | ROCK2 (0.68) | ROCK2CYP3A4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590950-B1 | N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL)BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-15 | — | — | EP | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| WO-2012006203-A1 | N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885CYP3A4 2215/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.