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ROCK2

Rho-associated protein kinase 2 · O75116 · ROCK2 on Sugi Atlas →

356,557 patent compounds predicted against ROCK2, 190,406 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Ripasudil Ripasudil (SCHEMBL31542) 1.00 13/20
SCHEMBL31541 SCHEMBL31541 0.70 12/20
SCHEMBL91397 SCHEMBL91397 0.62 12/20
Fasudil Fasudil (SCHEMBL4674) 1.00 8/20
SCHEMBL91529 SCHEMBL91529 0.70 8/20
SCHEMBL77629 SCHEMBL77629 0.68 8/20
Staurosporine Staurosporine (SCHEMBL8156) 1.00 7/20
Staurosporine Staurosporine (SCHEMBL8157) 1.00 7/20
SCHEMBL44674 SCHEMBL44674 0.50 7/20
SCHEMBL84462 SCHEMBL84462 0.53 6/20
SCHEMBL40212 SCHEMBL40212 0.38 6/20
SCHEMBL95142 SCHEMBL95142 1.00 5/20
SCHEMBL12872 SCHEMBL12872 0.59 5/20
SCHEMBL99955 SCHEMBL99955 0.53 5/20
SCHEMBL92545 SCHEMBL92545 0.39 5/20
SCHEMBL46547 SCHEMBL46547 0.38 5/20
SCHEMBL40113 SCHEMBL40113 0.38 5/20
Linifanib Linifanib (SCHEMBL93804) 1.00 4/20
SCHEMBL94862 SCHEMBL94862 0.97 4/20
SCHEMBL94964 SCHEMBL94964 0.79 4/20

Clinical trials — most relevant to ROCK2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study PHASE4COMPLETED
Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human PHASE4UNKNOWN
A Clinical Study on Fasudil Hydrochloride for Treatment of Gene-Specific Ovarian Cancer PHASE2RECRUITING
A Study of GSK2256098 and Trametinib in Advanced Pancreatic Cancer PHASE2COMPLETED
Simvastatin in Secondary Progressive Multiple Sclerosis PHASE2COMPLETED
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer PHASE2COMPLETED
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula PHASE2COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
SCARFREE-001: Verteporfin for Scar Prevention PHASE2NOT_YET_RECRUITING
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
A Study to Look at the Electrical Activity of the Heart in Subjects With Solid Tumor Cancers, Before and After Receiving the Study Treatment, GSK1120212 PHASE1COMPLETED
Phase I Study of AT13148, a Novel AGC Kinase Inhibitor PHASE1COMPLETED
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction EARLY_PHASE1RECRUITING
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 EARLY_PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
The Continuous Positive Airway Pressure Effect on Rho-associated Coiled-coil Containing Kinases Activity. nanUNKNOWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning nanCOMPLETED
Immune Cell Response to Stimuli nanRECRUITING
Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE) nanCOMPLETED
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle? nanUNKNOWN
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke nanCOMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms nanCOMPLETED
Screening and Identification of Biomarkers for High Myopia by a Rapid Method nanUNKNOWN
The Activation of Hippo Pathway in Nasal Polyps nanUNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a ROCK2 binder may also engage these)

ProteinNameSimilarity
Q62868 — 1.000 Q62868 →
Q28021 — 1.000 Q28021 →
M3TYT0 — 1.000 M3TYT0 →
P70336 — 1.000 P70336 →
ROCK1 Rho-associated protein kinase 1 1.000 landscape →
CDC42BPA Serine/threonine-protein kinase MRCK alpha 0.999 landscape →
P70335 — 0.999 P70335 →
O77819 — 0.999 O77819 →
O54874 — 0.998 O54874 →
Q63644 — 0.996 Q63644 →
CDC42BPB Serine/threonine-protein kinase MRCK beta 0.996 landscape →
Q5BJF6 — 0.994 Q5BJF6 →
Q3UU96 — 0.994 Q3UU96 →
Q7TT50 — 0.993 Q7TT50 →
Q5ZKK5 — 0.993 Q5ZKK5 →
Q8MIT6 — 0.992 Q8MIT6 →
P85120 — 0.992 P85120 →
O15078 — 0.992 O15078 →
Q6A078 — 0.991 Q6A078 →
Q6AYX5 — 0.991 Q6AYX5 →
A7MD70 — 0.991 A7MD70 →
Q6ZU80 — 0.990 Q6ZU80 →
A8WVU9 — 0.990 A8WVU9 →
Q7TT49 — 0.990 Q7TT49 →
A3KGV1 — 0.990 A3KGV1 →
Q6NRW2 — 0.989 Q6NRW2 →
Q9UJC3 — 0.989 Q9UJC3 →
Q9C099 — 0.989 Q9C099 →
Q8NCX0 — 0.989 Q8NCX0 →
P92199 — 0.988 P92199 →