SCHEMBL10022816

SCHEMBL10022816

O=COc1cccc(C(c2ccc(C(=O)O)c(C(=O)O)c2)(C(F)(F)F)C(F)(F)F)c1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.34
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 2/20 0.34
USP2 O75604 1/20 0.34
CYP2C19 P33261 1/20 0.34
SORT1 Q99523 7/20 0.34
MRGPRX4 Q96LA9 5/20 0.32
HPSE Q9Y251 1/20 0.32
CDC25A P30304 1/20 0.31
CDC25B P30305 1/20 0.31
GRIK1 P39086 1/20 0.31
PYGL P06737 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308976 0.82 HSD17B10 (0.41) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL4848176 0.81 HSD17B10 (0.40) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL16522345 0.81 ALDH1A1 (0.43) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL10700133 0.79 HSD17B10 (0.38) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL29401067 0.76 HSD17B10 (0.50) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL109108 0.76 HSD17B10 (0.50) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL9492931 0.76 HSD17B10 (0.50) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL1770132 0.76 HSD17B10 (0.50) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL29441324 0.76 HSD17B10 (0.50) HSD17B10KDM4EALDH1A1HPGDUSP2
SCHEMBL8473901 0.76 POLB (0.41) HSD17B10KDM4EALDH1A1HPGDUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8993710-B1 Polyimides derived from novel asymmetric benzophenone dianhydrides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 2015-03-31 US disclosed
US-8093348-B1 Polyimides derived from novel asymmetric dianhydrides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 2012-01-10 US disclosed