ALDH1A1

Aldehyde dehydrogenase 1A1 · P00352 · ALDH1A1 on Sugi Atlas →

8,863,219 patent compounds predicted against ALDH1A1, 3,924,826 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Tretinoin Tretinoin (SCHEMBL3145) 1.00 12/20
Tretinoin Tretinoin (SCHEMBL3146) 1.00 12/20
Retinol Retinol (SCHEMBL3112) 1.00 11/20
Retinol Retinol (SCHEMBL3113) 1.00 11/20
SCHEMBL2549 SCHEMBL2549 0.74 11/20
SCHEMBL3255 SCHEMBL3255 0.67 11/20
SCHEMBL3287 SCHEMBL3287 0.67 11/20
Aminosalicylic Acid Aminosalicylic Acid (SCHEMBL2262) 1.00 9/20
SCHEMBL1862 SCHEMBL1862 0.59 9/20
SCHEMBL1863 SCHEMBL1863 0.59 9/20
SCHEMBL2646 SCHEMBL2646 0.53 9/20
Aspirin Aspirin (SCHEMBL1353) 1.00 8/20
Diphenylamine Diphenylamine (SCHEMBL229) 0.92 8/20
SCHEMBL2313 SCHEMBL2313 0.74 8/20
Benzyl Benzoate Benzyl Benzoate (SCHEMBL3038) 0.69 8/20
Etocarlide Etocarlide (SCHEMBL676) 0.68 8/20
Etocarlide Etocarlide (SCHEMBL3292) 0.68 8/20
SCHEMBL422 SCHEMBL422 0.67 8/20
SCHEMBL2647 SCHEMBL2647 0.53 8/20
SCHEMBL3074 SCHEMBL3074 0.53 8/20

Clinical trials — most relevant to ALDH1A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Semaglutide and Vascular Regeneration PHASE4UNKNOWN
The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes PHASE4COMPLETED
Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients PHASE2UNKNOWN
Disulfiram and Cisplatin in Refractory TGCTs. PHASE2COMPLETED
Green Tea Extract in Treating Patients With Nonmetastatic Bladder Cancer PHASE2COMPLETED
Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor PHASE1/PHASE2COMPLETED
Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer PHASE2COMPLETED
Irinotecan and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Head and Neck Cancer PHASE2COMPLETED
Non-oxidative Metabolite Profiles After Increasing Doses of Ethanol PHASE1COMPLETED
Study of NK012 in Patients With Refractory Solid Tumors PHASE1COMPLETED
Safety Study of IHL-305 (Irinotecan Liposome Injection) to Treat Advanced Solid Tumors PHASE1COMPLETED
Phase I, Dose-Escalation Study of Dihydromyricetin (DHM) to Treat Alcohol-Associated Liver Disease PHASE1NOT_YET_RECRUITING
Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases PHASE1WITHDRAWN
ALDH2 Genetic Testing in East Asian Community nanNOT_YET_RECRUITING
Public Health Initiative on Alcohol Flushing nanCOMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion nanNOT_YET_RECRUITING
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
ADH1B and ALDH Gene Variants and Lung Cancer Risk nanNOT_YET_RECRUITING
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population nanUNKNOWN
ALDH1A1 Expression in Invasive Mammary Carcinoma nanUNKNOWN
The Genetic Basis for Vulnerability to Substance Abuse nanCOMPLETED
Hepatic Lipid Metabolism-Alcohol Use Disorder nanRECRUITING
Genetic and Environmental Risk Factors Related to Esophageal Cancer nanACTIVE_NOT_RECRUITING
Study of Protein Translocation in Patients With Beta-Oxidation Disorders nanCOMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer nanCOMPLETED
Evaluating the Safety and Pharmacokinetics of Raltegravir in Infants nanCOMPLETED
Adrenoleukodystrophy National Registry Study nanRECRUITING
Genetic Trial to Study Diarrhea in Patients With Stage III Colon Cancer Who Are Receiving Chemotherapy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALDH1A1 binder may also engage these)

ProteinNameSimilarity
P51977 1.000 P51977 →
Q8HYE4 1.000 Q8HYE4 →
P48644 1.000 P48644 →
P13601 1.000 P13601 →
Q8MI17 1.000 Q8MI17 →
P15437 1.000 P15437 →
Q28399 1.000 Q28399 →
P81178 1.000 P81178 →
P86886 1.000 P86886 →
Q29490 1.000 Q29490 →
P24549 1.000 P24549 →
ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 1.000 landscape →
P30841 1.000 P30841 →
ALDH1A3 Retinaldehyde dehydrogenase 3 1.000 landscape →
P51647 1.000 P51647 →
O35945 1.000 O35945 →
Q25417 1.000 Q25417 →
Q2XQV4 1.000 Q2XQV4 →
Q9SU63 1.000 Q9SU63 →
Q9JHW9 1.000 Q9JHW9 →
Q9CZS1 0.999 Q9CZS1 →
O93344 0.998 O93344 →
P46367 0.998 P46367 →
Q19A30 0.998 Q19A30 →
Q9I8W8 0.998 Q9I8W8 →
P28237 0.998 P28237 →
Q5R6B5 0.998 Q5R6B5 →
Q62148 0.998 Q62148 →
Q63639 0.997 Q63639 →
Q8K4D8 0.997 Q8K4D8 →