SCHEMBL10023967

SCHEMBL10023967

CCCc1ccc(N(c2ccccc2)c2ccc(-c3cccs3)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.50
PSMB5 P28074 2/20 0.48
CYP17A1 P05093 1/20 0.45
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
PRMT6 Q96LA8 1/20 0.39
KMT2A Q03164 2/20 0.39
PLA2G1B P04054 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
PPARG P37231 2/20 0.39
PPARA Q07869 2/20 0.39
FFAR1 O14842 2/20 0.38
APP P05067 1/20 0.38
GPR88 Q9GZN0 1/20 0.38
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
HCRTR1 O43613 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12356030 0.96 LTA4H (0.49) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL11887495 0.92 PSMB5 (0.44) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL11887484 0.90 LTA4H (0.49) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL14680785 0.89 LTA4H (0.47) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL10068366 0.88 PSMB5 (0.44) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL11990244 0.87 LTA4H (0.63) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL867469 0.86 LTA4H (0.50) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL14253104 0.86 LTA4H (0.50) LTA4HCYP17A1CYP11B1CYP11B2PRMT6
SCHEMBL11887476 0.85 PSMB5 (0.47) LTA4HPSMB5CYP17A1CYP11B1CYP11B2
SCHEMBL15591131 0.84 LTA4H (0.48) LTA4HCYP17A1CYP11B1CYP11B2PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8673523-B2 Image holding member for image forming apparatus, process cartridge, and image forming apparatus FUJI XEROX CO., LTD. (JP) 2014-03-18 US disclosed
US-8664645-B2 Organic electroluminescence element and display medium FUJI XEROX CO., LTD. (JP) 2014-03-04 US disclosed
US-8475981-B2 Image holding member for image forming apparatus, process cartridge, and image forming apparatus FUJI XEROX, CO., LTD. (JP) 2013-07-02 US disclosed
US-20120232242-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER FUJI XEROX CO., LTD. (JP) 2012-09-13 US disclosed
US-20120187384-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND DISPLAY MEDIUM FUJI XEROX CO., LTD. (JP) 2012-07-26 US disclosed
US-8207348-B2 Thiazolothiazole compound and thiazolothiazole polymer FUJI XEROX CO., LTD. (JP) 2012-06-26 US disclosed
US-20120015290-A1 IMAGE HOLDING MEMBER FOR IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2012-01-19 US disclosed
US-20110207040-A1 IMAGE HOLDING MEMBER FOR IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2011-08-25 US disclosed
US-20110086999-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER FUJI XEROX CO., LTD. (JP) 2011-04-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110086999-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER ARL1, IRAK1, TYK2 LTA4H 1699/4885PSMB5 2435/4885CYP17A1 1088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.