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Sugi Predict / Targets / LTA4H

LTA4H

Leukotriene A-4 hydrolase · P09960 · LTA4H on Sugi Atlas →

226,562 patent compounds predicted against LTA4H, 132,261 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL56495 SCHEMBL56495 0.90 11/20
Clodinafop Propargyl Clodinafop Propargyl (SCHEMBL63885) 0.44 9/20
Clodinafop Propargyl Clodinafop Propargyl (SCHEMBL63886) 0.44 9/20
Diphenylether Diphenylether (SCHEMBL12286) 1.00 7/20
Diphenylether Diphenylether (SCHEMBL51188) 0.71 7/20
SCHEMBL4698 SCHEMBL4698 0.67 7/20
SCHEMBL49434 SCHEMBL49434 0.67 7/20
SCHEMBL27593 SCHEMBL27593 0.66 7/20
SCHEMBL61732 SCHEMBL61732 0.57 7/20
SCHEMBL76698 SCHEMBL76698 0.50 7/20
SCHEMBL79800 SCHEMBL79800 0.50 7/20
Clodinafop Clodinafop (SCHEMBL21389) 0.48 7/20
SCHEMBL48203 SCHEMBL48203 0.47 7/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL47855) 0.46 7/20
SCHEMBL48055 SCHEMBL48055 0.39 7/20
Gingerol Gingerol (SCHEMBL32102) 1.00 6/20
SCHEMBL74847 SCHEMBL74847 1.00 6/20
SCHEMBL57167 SCHEMBL57167 0.88 6/20
SCHEMBL18198 SCHEMBL18198 0.78 6/20
SCHEMBL12355 SCHEMBL12355 0.67 6/20

Clinical trials — most relevant to LTA4H by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
TEAM (Trial on Efficacy and Quality of Life Among Asthmatic Patient With Montelukast) PHASE4COMPLETED
Open-label Study of the Effects of Montelukast in Patients With Chronic Cough PHASE4COMPLETED
Montelukast in Parkinson Disease PHASE2/PHASE3RECRUITING
Aspirin for Uncontrolled Asthma PHASE3COMPLETED
Montelukast for Early Life Wheezing PHASE2/PHASE3COMPLETED
Predicting the Response to Montelukast by Genetic Variation in Asthmatics PHASE3COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite PHASE2/PHASE3WITHDRAWN
Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis PHASE2/PHASE3UNKNOWN
Wheeze and Intermittent Treatment PHASE3COMPLETED
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients PHASE2/PHASE3COMPLETED
Treatment of Bronchial Asthma With Borage and Echium Seed Oils PHASE1/PHASE2COMPLETED
GSK2190915 Neutrophilic Asthma Study PHASE2COMPLETED
Investigation the Effect of Montelukast in COVID-19 PHASE2UNKNOWN
A Single Dose Study to Assess the Regional Absorption and Bioavailability of 100mg GSK2190915A PHASE1COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide PHASE1COMPLETED
GSK2190915A - Bioavailability Study PHASE1COMPLETED
MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial) EARLY_PHASE1RECRUITING
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing nanUNKNOWN
The Effectiveness of Montelukast on Atopic Dermatitis in Koreans nanCOMPLETED
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses nanCOMPLETED
Gender Differences and SNPs in Asthmatic Patients nanUNKNOWN
The Severe Asthma Research Program III-Boston Clinical Site nanCOMPLETED
Leukotriene Polymorphisms and Montelukast Response - Ancillary to LoDo Trial nanCOMPLETED
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B nanCOMPLETED
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma nanUNKNOWN
Modification of Allergic Immunologic Response by Leukotriene Antagonists - Ancillary to ACRN IMPACT nanCOMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms nanCOMPLETED
Montelukast in the Treatment of Duodenal Eosinophilia nanCOMPLETED
Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a LTA4H binder may also engage these)

ProteinNameSimilarity
Q6IP81 — 1.000 Q6IP81 →
Q3SZH7 — 1.000 Q3SZH7 →
P19602 — 1.000 P19602 →
Q6S9C8 — 1.000 Q6S9C8 →
Q5B0W8 — 0.998 Q5B0W8 →
P24527 — 0.997 P24527 →
G5EFT4 — 0.997 G5EFT4 →
P30349 — 0.995 P30349 →
A2QKF8 — 0.995 A2QKF8 →
A1DG68 — 0.994 A1DG68 →
Q6C3E5 — 0.993 Q6C3E5 →
O94544 — 0.993 O94544 →
Q2TZ99 — 0.992 Q2TZ99 →
Q1DVD1 — 0.992 Q1DVD1 →
P52922 — 0.991 P52922 →
Q0CFY9 — 0.991 Q0CFY9 →
A6RCT2 — 0.991 A6RCT2 →
Q7S785 — 0.991 Q7S785 →
Q0U653 — 0.990 Q0U653 →
Q4X265 — 0.990 Q4X265 →
A1CSI2 — 0.990 A1CSI2 →
A6SAG8 — 0.989 A6SAG8 →
Q10740 — 0.988 Q10740 →
Q2GY21 — 0.988 Q2GY21 →
A7EJL9 — 0.987 A7EJL9 →
A5DME6 — 0.987 A5DME6 →
Q6FTM0 — 0.987 Q6FTM0 →
A4QUC1 — 0.986 A4QUC1 →
A6ZS33 — 0.985 A6ZS33 →
A7THG7 — 0.985 A7THG7 →