Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025894 | 0.89 | MAPT (0.41) | ALDH1A1SMN1; SMN2L3MBTL1TSHRHSD11B1 | |
| SCHEMBL10025893 | 0.86 | P2RX7 (0.38) | ALDH1A1TSHRGRIN2CABCG2KDM4E | |
| SCHEMBL10025892 | 0.78 | P2RX7 (0.39) | GRIN2C | |
| SCHEMBL13809007 | 0.72 | GRIN2C (0.43) | ALDH1A1TSHRNPSR1GRIN2CABCB1 | |
| SCHEMBL13822114 | 0.71 | HCRTR1 (0.33) | MAPTTP53 | |
| SCHEMBL10025901 | 0.70 | PDE5A (0.39) | TSHRMAPT | |
| SCHEMBL10025913 | 0.70 | PDE5A (0.39) | TSHRMAPT | |
| SCHEMBL10025908 | 0.67 | P2RX7 (0.36) | TSHRGRIN2CPTGDR2 | |
| SCHEMBL10025896 | 0.66 | PTGDR2 (0.46) | TSHRPTGDR2 | |
| SCHEMBL13809019 | 0.66 | GRIN2C (0.44) | GRIN2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124616-B2 | Bicyclic PPAT inhibitors as antibacterial agents | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-02-28 | — | — | US | disclosed |
| US-8124616-B2 | Bicyclic PPAT inhibitors as antibacterial agents | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2012-02-28 | — | — | US | disclosed |
| US-20090203730-A1 | BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | MAXTHERA INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203730-A1 | BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | MAXTHERA INC. (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2009073534-A2 | BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | MAXTHERA INC. (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203730-A1 | BICYCLIC PPAT INHIBITORS AS ANTIBACTERIAL AGENTS | APRT, PPA1, GNPAT | ALDH1A1 1163/4885SMN1; SMN2 4735/4885L3MBTL1 2549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.