Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13331575 | 0.82 | TP53 (0.46) | TP53NPSR1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL85083 | 0.77 | ALDH1A1 (0.37) | TP53NPSR1CYP2D6ALDH1A1TSHR | |
| SCHEMBL10059958 | 0.75 | TP53 (0.43) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL719913 | 0.72 | TP53 (0.45) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL12322228 | 0.71 | TP53 (0.55) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL18559521 | 0.70 | TP53 (0.48) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL18754557 | 0.70 | TP53 (0.48) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL1316275 | 0.70 | TP53 (0.48) | TP53NPSR1CYP2D6HRH3ALDH1A1 | |
| SCHEMBL85616 | 0.70 | KMT2A (0.34) | TP53CYP2D6ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL15387055 | 0.70 | TP53 (0.48) | TP53NPSR1CYP2D6HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077794-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXSMITHKLINE LLC (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077794-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | MCHR1, MCHR2, MC1R | TP53 4237/4885NPSR1 9/4885CYP2D6 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.