Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.49 |
| ▸ | FOLR1 | P15328 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 4/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27098115 | 0.95 | FOLH1 (0.53) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL10026061 | 0.89 | PRMT1 (0.48) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL19627547 | 0.89 | FOLH1 (0.50) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL22131053 | 0.88 | FOLH1 (0.55) | FOLH1FOLR1HTR1APRMT1HRH2 | |
| SCHEMBL25714470 | 0.88 | FOLR1 (0.55) | FOLH1FOLR1HTR1APRMT1HRH2 | |
| SCHEMBL14703613 | 0.88 | FOLR1 (0.55) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL19869366 | 0.87 | FOLH1 (0.49) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL18874921 | 0.86 | FOLH1 (0.50) | FOLH1FOLR1HTR1APRMT1PRMT5 | |
| SCHEMBL22567811 | 0.86 | FOLH1 (0.53) | FOLH1FOLR1HTR1APRMT1HRH2 | |
| SCHEMBL17778915 | 0.86 | FOLH1 (0.57) | FOLH1FOLR1HTR1APRMT1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776977-B2 | PSMA-targeting compounds and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-9056841-B2 | PSMA-targeting compounds and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-06-16 | — | — | US | disclosed |
| US-20150104387-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-04-16 | — | — | US | disclosed |
| US-20120009121-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120009121-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | FOLH1, KLK3, PSMA2 | FOLH1 1/4885FOLR1 38/4885HTR1A 4600/4885 |
| US-20150104387-A1 | PSMA-TARGETING COMPOUNDS AND USES THEREOF | FOLH1, KLK3, PSMA2 | FOLH1 1/4885FOLR1 38/4885HTR1A 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.