Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14783326 | 0.74 | NT5E (0.55) | METAKT1AKT2NT5ECHEK1 | |
| SCHEMBL29393610 | 0.73 | CHEK1 (0.41) | METAKT1AKT2MAPK1CHEK1 | |
| SCHEMBL509620 | 0.72 | FYN (0.53) | MET | |
| SCHEMBL4502162 | 0.69 | FYN (0.52) | METKDM4EHSD17B10CYP1A2 | |
| SCHEMBL16554996 | 0.68 | DYRK1A (0.59) | AKT1AKT2MAPK1CHEK1CHEK2 | |
| SCHEMBL4247015 | 0.68 | KDM4E (0.64) | METKDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL8646848 | 0.67 | KDM4E (0.38) | KDM4EHSD17B10BRD4MEN1KMT2A | |
| SCHEMBL3740850 | 0.65 | AKT2 (0.70) | AKT1AKT2MAPK1CHEK1CHEK2 | |
| SCHEMBL31028985 | 0.65 | KMT2A (0.52) | AKT1AKT2MAPK1CHEK1CHEK2 | |
| SCHEMBL10763003 | 0.64 | KDM4E (0.35) | KDM4EHSD17B10BRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012015677-A9 | 6-(1-METHYL-1H-PYRAZOL-4-YL)-3-(2-METHYL-2H-INDAZOL-5-YLTHIO)-[1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE AS A C-MET INHIBITOR | ELI LILLY AND COMPANY (US) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012015677-A1 | 6- (1-METHYL-1H-PYRAZOL-4-YL)-3-(2-METHYL-2H-INDAZOL-5- | ELI LILLY AND COMPANY (US) | 2012-02-02 | — | — | WO | disclosed |