Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14268265 | 0.97 | SCNN1A (0.59) | SCNN1AKCNH2 | |
| SCHEMBL16383916 | 0.95 | SCNN1A (0.55) | SCNN1AKCNH2 | |
| SCHEMBL14268273 | 0.95 | SCNN1A (0.55) | SCNN1AKCNH2 | |
| SCHEMBL17806175 | 0.95 | SCNN1A (0.56) | SCNN1A | |
| SCHEMBL12251733 | 0.93 | SCNN1A (0.55) | SCNN1A | |
| SCHEMBL706204 | 0.93 | SCNN1A (0.51) | SCNN1A | |
| SCHEMBL9913766 | 0.93 | SCNN1A (0.58) | SCNN1AKCNH2 | |
| SCHEMBL12251675 | 0.93 | SCNN1A (0.58) | SCNN1AKCNH2 | |
| SCHEMBL9913788 | 0.93 | SCNN1A (0.56) | SCNN1AKCNH2 | |
| SCHEMBL17809466 | 0.92 | SCNN1A (0.56) | SCNN1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267650-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20150376146-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2015-12-31 | — | — | US | disclosed |
| WO-2015003083-A1 | COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-01-08 | — | — | WO | disclosed |
| US-8846688-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140179625-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20130012692-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8314105-B2 | Methods of reducing risk of infection from pathogens | PARION SCIENCES, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120165342-A1 | Methods of Reducing Risk of Infection from Pathogens | PARION SCIENCES, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20110144338-A1 | METHODS OF REDUCING RISK OF INFECTION FROM PATHOGENS | PARION SCIENCES, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-7875619-B2 | N-[4-(4-{2-[bis-((2S,3R)-2,3,4-trihydroxybutyl)amino]ethylamino}phenyl)butyl]-N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidine trihydrochloride; treating chronic bronchitis, cystic fibrosis, ventilator-induced pneumonia, asthma, chronic obstructive pulmonary disease, pneumonia and emphysema | PARION SCIENCES, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7332496-B2 | Broncholdilator agents; hydration of mucous membranes; respiratory system disorders | PARION SCIENCES, INC. (US) | 2008-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267650-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885KCNH2 13/4885 |
| US-20150376146-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885KCNH2 13/4885 |
| US-20120165342-A1 | Methods of Reducing Risk of Infection from Pathogens | KCNN3, KCNN1, KCNN2 | SCNN1A 14/4885KCNH2 54/4885 |
| US-20110144338-A1 | METHODS OF REDUCING RISK OF INFECTION FROM PATHOGENS | KCNN3, KCNN1, KCNN2 | SCNN1A 14/4885KCNH2 54/4885 |
| US-20140179625-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885KCNH2 13/4885 |
| US-20130012692-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885KCNH2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.