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KCNN3

Small conductance calcium-activated potassium channel protein 3 · Q9UGI6 · KCNN3 on Sugi Atlas →

7,218 patent compounds predicted against KCNN3, 4,220 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL902740 SCHEMBL902740 0.67 14/20
SCHEMBL1934962 SCHEMBL1934962 0.58 14/20
SCHEMBL1934303 SCHEMBL1934303 0.58 14/20
SCHEMBL45705 SCHEMBL45705 0.57 14/20
SCHEMBL2033397 SCHEMBL2033397 0.52 14/20
SCHEMBL29869 SCHEMBL29869 0.51 14/20
SCHEMBL30974 SCHEMBL30974 0.49 14/20
SCHEMBL1290450 SCHEMBL1290450 0.49 14/20
SCHEMBL860305 SCHEMBL860305 0.46 14/20
SCHEMBL861490 SCHEMBL861490 0.46 14/20
SCHEMBL860641 SCHEMBL860641 0.44 14/20
SCHEMBL860517 SCHEMBL860517 0.50 12/20
SCHEMBL1695626 SCHEMBL1695626 0.37 12/20
SCHEMBL1072883 SCHEMBL1072883 0.54 11/20
SCHEMBL1018372 SCHEMBL1018372 0.39 11/20
SCHEMBL659433 SCHEMBL659433 0.40 8/20
SCHEMBL901809 SCHEMBL901809 0.43 7/20
SCHEMBL901958 SCHEMBL901958 0.36 6/20
SCHEMBL1523664 SCHEMBL1523664 0.57 5/20
SCHEMBL901256 SCHEMBL901256 0.46 5/20

Clinical trials — most relevant to KCNN3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study PHASE4COMPLETED
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation PHASE3COMPLETED
Role of Intralipid in Management of Organophosphorus Poisoning PHASE2/PHASE3WITHDRAWN
A Clinical Study to Evaluate CAD-1883 in Essential Tremor PHASE2COMPLETED
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients PHASE2COMPLETED
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease PHASE2COMPLETED
4-Aminopyridine in Episodic Ataxia Type 2 PHASE2WITHDRAWN
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy PHASE1/PHASE2RECRUITING
Safety, Blood Levels and Effects of AUT00201 in Patients With MEAK PHASE1COMPLETED
A First-in-Human SAD and MAD Study in Healthy Participants to Evaluate Oral YR011 Tablet PHASE1NOT_YET_RECRUITING
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies nanUNKNOWN
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients. nanUNKNOWN
Genetic Determinants of Sudden Cardiac Death nanCOMPLETED
The Physiological Effects of Human Ether-a-go-go-Related Gene (hERG)Blockade on Metabolism nanCOMPLETED
A Positional Cloning Study on Schizophrenia nanCOMPLETED
Feasibility of Improving Risk Stratification in Brugada Syndrome nanCOMPLETED
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives nanUNKNOWN
A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy nanUNKNOWN
Qatar Cardiovascular Biorepository of AF Patients nanUNKNOWN
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA) nanUNKNOWN
Involvement of SK3 Calcium Channel in Taxane Neuropathy nanCOMPLETED
Registry of Unexplained Cardiac Arrest nanCOMPLETED
Safety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency nanCOMPLETED
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia nanUNKNOWN
Factors Affecting Salt Intake in Young Adults nanUNKNOWN
Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF nanCOMPLETED
The Use of Antiarrhythmic Drugs in Pediatrics nanUNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain. nanUNKNOWN
Painful Channelopathies Study nanUNKNOWN
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a KCNN3 binder may also engage these)

ProteinNameSimilarity
P58392 — 1.000 P58392 →
P58391 — 1.000 P58391 →
P70605 — 1.000 P70605 →
P58390 — 0.999 P58390 →
Q23985 — 0.989 Q23985 →
Q9VML1 — 0.988 Q9VML1 →
P08510 — 0.987 P08510 →
Q7KVW5 — 0.987 Q7KVW5 →
Q9VM91 — 0.986 Q9VM91 →
P70604 — 0.986 P70604 →
P49882 — 0.985 P49882 →
P91682 — 0.985 P91682 →
P97414 — 0.985 P97414 →
F1QLY4 — 0.985 F1QLY4 →
Q9W5A5 — 0.985 Q9W5A5 →
HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 0.985 landscape →
Q9JJP2 — 0.985 Q9JJP2 →
P84903 — 0.985 P84903 →
STIM1 Stromal interaction molecule 1 0.984 landscape →
Q02280 — 0.984 Q02280 →
A0JMA8 — 0.984 A0JMA8 →
O88704 — 0.984 O88704 →
Q9VVI2 — 0.984 Q9VVI2 →
P19785 — 0.984 P19785 →
G5EF60 — 0.984 G5EF60 →
A2VEY9 — 0.984 A2VEY9 →
Q05192 — 0.984 Q05192 →
DAGLA Diacylglycerol lipase-alpha 0.984 landscape →
P51448 — 0.983 P51448 →
Q90416 — 0.983 Q90416 →