SCHEMBL10032982 — predicted protein targets

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	7/20	0.38

▸	PSEN2	P49810	7/20	0.38

▸	APH1B	Q8WW43	7/20	0.38

▸	NCSTN	Q92542	7/20	0.38

▸	APH1A	Q96BI3	7/20	0.38

▸	PSENEN	Q9NZ42	7/20	0.38

▸	CCRL2	O00421	1/20	0.34

▸	DRD2	P14416	1/20	0.33

▸	OPRM1	P35372	1/20	0.33

▸	DRD3	P35462	1/20	0.33

▸	TACR1	P25103	1/20	0.31

▸	GPR88	Q9GZN0	1/20	0.31

▸	ATM	Q13315	1/20	0.31

▸	SLC18A2	Q05940	1/20	0.30

▸	P2RY14	Q15391	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6918641	0.84	PSEN1 (0.44)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2315797	0.81	PSEN1 (0.54)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2359941	0.81	PSEN1 (0.54)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL13836441	0.81	PSEN1 (0.54)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL13964513	0.79	PSEN1 (0.39)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL13964516	0.76	PSEN1 (0.49)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL6917898	0.75	PSEN1 (0.44)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL10033194	0.73	PSEN1 (0.43)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2319230	0.72	PSEN1 (0.43)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2358338	0.71	GPR88 (0.35)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012046771-A1	CYCLOALKANE COMPOUND	アステラス製薬株式会社 (JP)	2012-04-12	—	—	WO	disclosed