GPR88 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1584334	1.00	20/20
SCHEMBL1584958	1.00	20/20
SCHEMBL1584961	1.00	20/20
SCHEMBL1585230	1.00	20/20
SCHEMBL2496251	1.00	20/20
SCHEMBL2496255	1.00	20/20
SCHEMBL2497366	1.00	20/20
SCHEMBL2499207	1.00	20/20
SCHEMBL2501446	1.00	20/20
SCHEMBL2501521	1.00	20/20
SCHEMBL2501535	1.00	20/20
SCHEMBL2501540	1.00	20/20
SCHEMBL2501904	1.00	20/20
SCHEMBL2502024	1.00	20/20
SCHEMBL2502387	1.00	20/20
SCHEMBL2502436	1.00	20/20
SCHEMBL2504950	1.00	20/20
SCHEMBL2505071	1.00	20/20
SCHEMBL2505108	1.00	20/20
SCHEMBL2505806	1.00	20/20

Clinical trials — most relevant to GPR88 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration	PHASE2	WITHDRAWN
Dose Ranging Study of Carbidopa-levodopa	PHASE2	COMPLETED
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study	PHASE1	UNKNOWN
Effect of GSK962040 on Oesophageal Function	PHASE1	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Fat-induced Release of GLP-1 in Humans	nan	COMPLETED
Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
Gastroparesis Registry 3	nan	COMPLETED
GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma	nan	UNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR88 binder may also engage these)

Protein	Name	Similarity
Q9ESP4	—	1.000	Q9ESP4 →
Q9EPB7	—	0.998	Q9EPB7 →
Q9XT57	—	0.980	Q9XT57 →
P34971	—	0.978	P34971 →
Q80UC6	—	0.978	Q80UC6 →
O02662	—	0.978	O02662 →
ADRB3	Beta-3 adrenergic receptor	0.977	landscape →
Q8BL07	—	0.977	Q8BL07 →
Q9XT58	—	0.976	Q9XT58 →
P46626	—	0.976	P46626 →
Q28998	—	0.975	Q28998 →
Q9TST4	—	0.975	Q9TST4 →
ADRA2C	Alpha-2C adrenergic receptor	0.975	landscape →
Q8IZ08	—	0.975	Q8IZ08 →
Q8NGU9	—	0.974	Q8NGU9 →
Q95252	—	0.973	Q95252 →
Q60483	—	0.973	Q60483 →
Q28524	—	0.973	Q28524 →
Q7TQN7	—	0.972	Q7TQN7 →
P47899	—	0.972	P47899 →
Q9BZJ7	—	0.972	Q9BZJ7 →
P26255	—	0.971	P26255 →
MTNR1B	Melatonin receptor type 1B	0.971	landscape →
Q924U1	—	0.971	Q924U1 →
P25962	—	0.971	P25962 →
NTSR2	Neurotensin receptor type 2	0.970	landscape →
Q9TT96	—	0.970	Q9TT96 →
O02666	—	0.970	O02666 →
KISS1R	KiSS-1 receptor	0.970	landscape →
P31387	—	0.969	P31387 →