Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.71 |
| ▸ | SLCO1B3 | Q9NPD5 | 8/20 | 0.71 |
| ▸ | SLCO1B1 | Q9Y6L6 | 8/20 | 0.71 |
| ▸ | TP53 | P04637 | 5/20 | 0.71 |
| ▸ | USP2 | O75604 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12998468 | 0.83 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL12998455 | 0.82 | CYP3A4 (0.63) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL15414716 | 0.78 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL25034707 | 0.72 | CYP3A4 (0.70) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL13456007 | 0.70 | CYP3A4 (0.80) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL10019477 | 0.68 | CYP3A4 (0.77) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL800981 | 0.68 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL10019460 | 0.68 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| SCHEMBL14196982 | 0.68 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 | |
| 3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL13424818 | 0.67 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1TP53USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157474-A1 | Methods of Identifying and Using General or Alternative Splicing Inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-06-21 | — | — | US | disclosed |