SCHEMBL10035142

SCHEMBL10035142

COc1ccc(-c2ccc(C3CCC(C)CC3)c(F)c2F)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 10/20 0.36
FEN1 P39748 10/20 0.36
FPR2 P25090 4/20 0.36
HTR2C P28335 1/20 0.33
USP30 Q70CQ3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16922997 1.00 ALOX5AP (0.36) ALOX5APFEN1FPR2HTR2CUSP30
SCHEMBL13868125 0.96 ALOX5AP (0.34) ALOX5APFEN1FPR2USP30
SCHEMBL803458 0.96 ALOX5AP (0.34) ALOX5APFEN1FPR2USP30
SCHEMBL170527 0.94 HTR2C (0.37) ALOX5APFEN1HTR2CUSP30
SCHEMBL12999898 0.93 ALOX5AP (0.41) ALOX5APFEN1FPR2
SCHEMBL172469 0.89 HTR2C (0.34) ALOX5APFEN1HTR2CUSP30
SCHEMBL13000031 0.89 ALOX5AP (0.39) ALOX5APFEN1FPR2
SCHEMBL12437063 0.87 ESR2 (0.38) ALOX5APFEN1
SCHEMBL19754822 0.87 ESR2 (0.38) ALOX5APFEN1
SCHEMBL172422 0.87 ESR2 (0.38) ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11739266-B2 Polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2023-08-29 US disclosed
US-11685863-B2 Polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2023-06-27 US disclosed
US-11655417-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2023-05-23 US disclosed
US-20180201837-A1 Method of Reducing ODF Mura in Polymer Stabilised Liquid Crystal Displays MERCK PATENT GMBH (DE) 2018-07-19 US disclosed
US-20180179446-A1 LIQUID CRYSTAL MEDIUM CONTAINING POLYMERISABLE COMPOUNDS MERCK PATENT GMBH (DE) 2018-06-28 US disclosed
US-20180134959-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2018-05-17 US disclosed
US-9963637-B2 Liquid crystal medium MERCK PATENT GMBH (DE) 2018-05-08 US disclosed
US-9938229-B2 Polymerisable compounds and the use thereof in liquid-crystal displays MERCK PATENT GMBH (DE) 2018-04-10 US disclosed
US-9926490-B2 Liquid crystal medium MERCK PATENT GMBH (DE) 2018-03-27 US disclosed
US-20180079959-A1 LIQUID CRYSTAL ELEMENT WITH NEGATIVE DIELECTRIC ANISOTROPY DIC CORPORATION (JP) 2018-03-22 US disclosed
US-20150267119-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2015-09-24 US disclosed
US-20150205158-A1 LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2015-07-23 US disclosed
US-20150070609-A1 LIQUID CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2015-03-12 US disclosed
US-20140375943-A1 POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2014-12-25 US disclosed
US-20140139786-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS MERCK PATENT GMBH (DE) 2014-05-22 US disclosed
US-8114310-B2 Liquid-crystal display MERCK PATENT GMBH (DE) 2012-02-14 US disclosed
US-7731865-B2 Liquid-crystal medium MERCK PATENT GMBH (DE) 2010-06-08 US disclosed
US-20090324853-A1 LIQUID-CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2009-12-31 US disclosed
US-20090103011-A1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GESELLSCHAFT (DE) 2009-04-23 US disclosed
US-7440160-B2 Electro-optical light modulating element, electro-optical display and modulating medium MERCK PATENT GMBH (DE) 2008-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11685863-B2 Polymerisable compounds and the use thereof in liquid-crystal displays LPXN, VCL, LCP1 ALOX5AP 1418/4885FEN1 3301/4885FPR2 3835/4885
US-20150267119-A1 POLYMERISABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS LPXN, VCL, LCP1 ALOX5AP 1393/4885FEN1 4113/4885FPR2 2765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.