Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036165 | 0.91 | SIRT6 (0.65) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL13247587 | 0.91 | SIRT6 (0.73) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL22466180 | 0.91 | MAPT (0.57) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL22471328 | 0.87 | SIRT6 (0.67) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL25797079 | 0.82 | CRBN (0.52) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL22466224 | 0.81 | SIRT6 (0.58) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL22175056 | 0.81 | SIRT6 (0.63) | SIRT6LMNACRBNMAPTALDH1A1 | |
| SCHEMBL447471 | 0.79 | SIRT6 (1.00) | SIRT6LMNAMAPTALDH1A1POLB | |
| SCHEMBL4290276 | 0.79 | ESRRG (0.63) | SIRT6CRBNMAPTALDH1A1POLB | |
| SCHEMBL4290270 | 0.79 | ESRRG (0.63) | SIRT6CRBNMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053606-A1 | ARYLAMINOHETEROCYCLIC CARBOXAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2012-04-26 | — | — | WO | disclosed |