Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14988176 | 0.96 | CSNK1A1 (0.40) | SMN1; SMN2NSD2MAPK1KDM4ECSNK1A1 | |
| SCHEMBL30886311 | 0.85 | KHK (0.40) | SMN1; SMN2CSNK1A1CLK4ALDH1A1NPSR1 | |
| SCHEMBL25020899 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1TDP1HTTL3MBTL1 | |
| SCHEMBL14998531 | 0.74 | CSNK1A1 (0.39) | SMN1; SMN2CSNK1A1CLK4ALDH1A1NPSR1 | |
| SCHEMBL27846918 | 0.74 | ALDH1A1 (0.36) | SMN1; SMN2MAPK1KDM4ECSNK1A1CLK4 | |
| SCHEMBL27687020 | 0.74 | ALDH1A1 (0.36) | SMN1; SMN2MAPK1KDM4ECSNK1A1CLK4 | |
| SCHEMBL22890488 | 0.73 | KDM4E (0.42) | MAPK1KDM4ECSNK1A1CLK4ALDH1A1 | |
| SCHEMBL14988456 | 0.72 | ALDH1A1 (0.36) | MAPK1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7815570 | 0.70 | CSNK1A1 (0.45) | SMN1; SMN2KDM4ECSNK1A1CLK4ALDH1A1 | |
| SCHEMBL3826388 | 0.69 | CSNK1A1 (0.41) | KDM4ECSNK1A1CLK4ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2599774-B1 | CONDENSED PYRIDINE COMPOUNDS AS CB2 CANNABINOID RECEPTOR LIGANDS | ASTELLAS PHARMA INC (JP) | 2016-07-06 | — | — | EP | disclosed |
| US-8791106-B2 | Fused ring pyridine compound | ASTELLAS PHARMA INC. (JP) | 2014-07-29 | — | — | US | disclosed |
| US-8791106-B2 | Fused ring pyridine compound | ASTELLAS PHARMA INC. (JP) | 2014-07-29 | — | — | US | disclosed |
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-06 | — | — | US | disclosed |
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-06-06 | — | — | US | disclosed |
| EP-2599774-A1 | CONDENSED RING PYRIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| EP-2599774-A1 | CONDENSED RING PYRIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012014963-A1 | CONDENSED RING PYRIDINE COMPOUND | アステラス製薬株式会社 (JP) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143874-A1 | FUSED RING PYRIDINE COMPOUND | CNR2, CNR1, TRPV1 | SMN1; SMN2 3187/4885NSD2 2937/4885MAPK1 2223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.