SCHEMBL10040997

SCHEMBL10040997

CCOc1ccc(Cc2cc([C@]3(OC)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)c(F)c1F

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 14/20 0.49
SLC5A1 P13866 12/20 0.49
ADRA2A P08913 1/20 0.40
SLC5A11 Q8WWX8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17690463 1.00 SLC5A2 (0.49) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL17108913 0.94 SLC5A2 (0.46) SLC5A2SLC5A1
SCHEMBL14954992 0.93 SLC5A2 (0.43) SLC5A2SLC5A1
SCHEMBL15015858 0.91 SLC5A2 (0.42) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL10041210 0.87 SLC5A2 (0.61) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL17108898 0.87 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL18214905 0.87 SLC5A2 (0.49) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14955060 0.86 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL15041080 0.86 SLC5A2 (0.41) SLC5A2SLC5A1
SCHEMBL10041216 0.84 SLC5A2 (0.39) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2895490-B1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SUNSHINE LAKE PHARMA CO LTD (CN) 2016-10-19 EP disclosed
EP-2895490-B1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SUNSHINE LAKE PHARMA CO LTD (CN) 2016-10-19 EP disclosed
US-9394329-B2 Glucopyranosyl derivatives and their uses in medicine SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-07-19 US disclosed
US-9394329-B2 Glucopyranosyl derivatives and their uses in medicine SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-07-19 US disclosed
US-9394329-B2 Glucopyranosyl derivatives and their uses in medicine SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-07-19 US disclosed
EP-2604612-B1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION RPOCESS AND PHARMACEUTICAL USE THEREOF SHANGHAI HENGRUI PHARM CO LTD (CN) 2016-04-20 EP disclosed
EP-2604612-B1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION RPOCESS AND PHARMACEUTICAL USE THEREOF SHANGHAI HENGRUI PHARM CO LTD (CN) 2016-04-20 EP disclosed
US-20150266916-A1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-09-24 US disclosed
US-20150266916-A1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-09-24 US disclosed
US-20150266916-A1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-09-24 US disclosed
US-8609622-B2 C-aryl glucoside derivatives, preparation process and pharmaceutical use thereof SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2013-12-17 US disclosed
EP-2604612-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION RPOCESS AND PHARMACEUTICAL USE THEREOF Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) 2013-06-19 EP disclosed
EP-2604612-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION RPOCESS AND PHARMACEUTICAL USE THEREOF Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) 2013-06-19 EP disclosed
US-20130130997-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2013-05-23 US disclosed
US-20130130997-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2013-05-23 US disclosed
US-20130130997-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF JIANGSU HENGRUI MEDICINE CO., LTD. (CN) 2013-05-23 US disclosed
WO-2012019496-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION RPOCESS AND PHARMACEUTICAL USE THEREOF 上海恒瑞医药有限公司 (CN) 2012-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150266916-A1 GLUCOPYRANOSYL DERIVATIVES AND THEIR USES IN MEDICINE SLC5A2, SLC5A1, UGGT1 SLC5A2 1/4885SLC5A1 2/4885ADRA2A 1045/4885
US-20130130997-A1 C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF SLC5A1, SLC5A2, UGGT1 SLC5A2 2/4885SLC5A1 1/4885ADRA2A 1060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.