SCHEMBL10041265

SCHEMBL10041265

CC(C)(C)c1nc2cccnc2n1-c1cccc(-n2c(C(C)(C)C)nc3cccnc32)c1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 11/20 0.52
PDE4D Q08499 10/20 0.52
AKT1 P31749 2/20 0.45
AKT2 P31751 2/20 0.45
AKT3 Q9Y243 1/20 0.45
RXFP1 Q9HBX9 1/20 0.41
TP53 P04637 1/20 0.41
ITGB1 P05556 1/20 0.40
ITGA4 P13612 1/20 0.40
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
PABPC1 P11940 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10041273 0.92 PDE4B (0.46) PDE4BPDE4DAKT1AKT2AKT3
SCHEMBL14124485 0.77 AKT1 (0.46) PDE4BPDE4DAKT1AKT2AKT3
SCHEMBL10041258 0.76 MAPK1 (0.49) MEN1POLBKMT2A
SCHEMBL10041264 0.76 BACE1 (0.35) PDE4BPDE4DMEN1KMT2A
SCHEMBL12724785 0.76 RAB9A (0.43) PDE4BPDE4DAKT1AKT2AKT3
SCHEMBL19072663 0.72 PDE4B (0.82) PDE4BPDE4D
SCHEMBL13052922 0.72 PDE10A (0.56) PDE4BAKT1AKT2RXFP1TP53
SCHEMBL10041268 0.72 RPS6KA5 (0.41) TP53POLB
SCHEMBL10041270 0.72 AOC3 (0.39)
SCHEMBL13916710 0.71 PDE4B (0.55) PDE4BPDE4DAKT1AKT2AKT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8147987-B2 Organic electroluminescent element and compounds for use in the element FUJIFILM CORPORATION (JP) 2012-04-03 US disclosed
US-8147987-B2 Organic electroluminescent element and compounds for use in the element FUJIFILM CORPORATION (JP) 2012-04-03 US disclosed
US-20070202357-A1 Organic electroluminescent element and compounds for use in the element FUJIFILM CORPORATION (JP) 2007-08-30 US disclosed
US-20070202357-A1 Organic electroluminescent element and compounds for use in the element FUJIFILM CORPORATION (JP) 2007-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070202357-A1 Organic electroluminescent element and compounds for use in the element RPL31, RPL38, RPL39 PDE4B 4561/4885PDE4D 4813/4885AKT1 3723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.