Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL738024 | 0.84 | KMT2A (0.57) | KMT2AMEN1LMNAKDM4EALDH1A1 | |
| SCHEMBL761932 | 0.82 | KMT2A (0.48) | KMT2AMEN1HPGDRAB9APTGS2 | |
| SCHEMBL739340 | 0.78 | MEN1 (0.45) | KMT2AMEN1LMNAMAPTHTT | |
| SCHEMBL740850 | 0.77 | MEN1 (0.44) | KMT2AMEN1 | |
| SCHEMBL739570 | 0.77 | MEN1 (0.44) | KMT2AMEN1 | |
| SCHEMBL22672253 | 0.71 | KMT2A (0.62) | KMT2AMEN1LMNAMAPTHSD17B10 | |
| SCHEMBL30203914 | 0.71 | KMT2A (0.62) | KMT2AMEN1LMNAMAPTHSD17B10 | |
| SCHEMBL10042008 | 0.71 | MEN1 (0.43) | KMT2AMEN1RAB9ATUBB4ATUBB | |
| SCHEMBL740901 | 0.71 | PTPN1 (0.49) | KMT2AMEN1MAPT | |
| SCHEMBL737423 | 0.70 | PTPN1 (0.49) | KMT2AMEN1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138184-B2 | Isoxazole derivatives and pharmaceutical compositions comprising the same | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-03-20 | — | — | US | disclosed |
| US-20090215768-A1 | ISOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215768-A1 | ISOXAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | TBXA2R, F12, PTH1R | KMT2A 2590/4885MEN1 563/4885LMNA 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.