Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 18/20 | 0.61 |
| ▸ | LY96 | Q9Y6Y9 | 5/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12762979 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL12600978 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL13803798 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL14080323 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL12601329 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL10070896 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL13791954 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL12600779 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL12601198 | 1.00 | TLR4 (0.61) | TLR4LY96LPAR1 | |
| SCHEMBL14136950 | 0.94 | TLR4 (0.53) | TLR4LY96 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399634-B2 | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8207144-B2 | Improves the stability over time of a corresponding tetrasodium salt useful as a preventive or therapeutic for septicemia, endotoxemia or improving prognosis following coronary artery bypass surgery | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-7906633-B2 | Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-15 | — | — | US | disclosed |
| US-20100152429-A1 | SODIUM SALT OF DISACCHARIDE COMPOUND, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
| US-20090149647-A1 | PROCESS FOR PRODUCTION OF LIPID A ANALOGUE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-11 | — | — | US | disclosed |
| US-20080227991-A1 | Sodium salt of disaccharide compound, production method and use of same | EISAI R&D MANAGEMENT CO., LTD. | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149647-A1 | PROCESS FOR PRODUCTION OF LIPID A ANALOGUE | DDOST, PHOSPHO1, DCPS | TLR4 2691/4885LY96 3397/4885LPAR1 162/4885 |
| US-20080227991-A1 | Sodium salt of disaccharide compound, production method and use of same | MAN2A1, MAN2B2, MAN2B1 | TLR4 557/4885LY96 4701/4885LPAR1 1020/4885 |
| US-20100152429-A1 | SODIUM SALT OF DISACCHARIDE COMPOUND, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME | MAN2B2, MAN2A1, MAN2B1 | TLR4 1500/4885LY96 4612/4885LPAR1 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.